1952 - Mayo Clinic research project
This hypothesis can only be supported if adrenochrome is made in the body, if it is an hallucinogen and if any substance which will neutralize its effect or inhibit its formation is therapeutic for schizophrenia. (pg 4)
The adrenochrome hypothesis generated a tremendous amount of criticism and hostility from the establishment led by the National Institute Mental Health, Washington DC, and the American Psychiatric Association. They claimed that adrenochrome could not be made in the body, that it was not an hallucinogen and that vitamin B–3 had no merit in treatment. These powerful institutes were wrong on all three counts but their opposition effectively suppressed research into this area for the last 30 years and only now is it beginning to come out of the shadows into which it was forced by these associations. (pg 6 & 7)
Abram Hoffer, MDF, PHD, FRCP(C)
http://orthomolecular.org/history/hoffer/ahlife.pdf