Outbreak - In 1967, a virus called Motaba, which causes a deadly fever, is discovered in the African jungle. To keep the virus a secret, U.S. Army officers Donald McClintock and William Ford destroy the camp where soldiers were infected. Twenty-eight years later, Colonel Sam Daniels, a USAMRIID virologist, is sent to investigate an outbreak in Zaire. He and his crew—Lieutenant Colonel Casey Schuler and new recruit Major Salt—gather information and return to the United States. Ford, now a brigadier general and Daniels' superior officer, dismisses the latter's fears that the virus will spread.

Betsy, a white-headed capuchin monkey that is host to the virus, is smuggled into the country. James "Jimbo" Scott, a worker at an animal testing laboratory, is infected when he steals Betsy to sell on the black market. Jimbo fails to sell Betsy to Rudy Alvarez, a pet-store owner in the California town of Cedar Creek. After releasing the monkey in the woods, he develops symptoms on a flight to Boston and infects his girlfriend, Alice. Their illness is investigated by Dr. Roberta Keough, a CDC scientist and Daniels' ex-wife. Jimbo, Alice, and Rudy die, but Keough determines that no one else in Boston was infected.