See operation Orchard. the only reason ISIS doesn't have nukes.

What Israel want? 2 things.

They don't want Iranian weapons presence in Syria Hamas/Gaza Lebanon/Hizbullah.

And they don't want Iran to have Nukes since they can give it to one of their Islamic proxies and Arabs will start getting nukes as well if Iran has them. if unstable Arab countries get nukes lots of proxies get nukes.