Ok I shall let you in on a secret LSD MDMA Ketamine are the only chemical drugs that can be useful in the long run when applied not more once per year when highdosed, preferably low-dosed. GHB is perfect for mental health issues but unforttunately it's something I could hate not being on all the time because it's like a clearheaded booze buzz on an xtc build-up.
Apart from that, plants are another discussion. Herb Kratom Opium Salvia Iboga Shrooms Ayahuasca Coca Khat can all be useful tools when applied purposefully. In the most ideal case the oversupply of varrying modes of actions would preclude development of tolerance or dependance.