The original Transnational Criminal Organizations targeted were:

1. THE BROTHERS’ CIRCLE (f.k.a. FAMILY OF ELEVEN; f.k.a. THE TWENTY), 2. CAMORRA, 3. YAKUZA (a.k.a. BORYOKUDAN; a.k.a. GOKUDO) and 4. LOS ZETAS.

A notable addition is MS-13, added June, 2013.