From 1993–1995, Rothschild served on President Bill Clinton's National Information Infrastructure Advisory Council. From 1998–2000, she served on the US Secretary of Energy's Advisory Committee.[8]
Rothschild has donated to all of Bill and Hillary Clinton's federal races since 1992.[10] Although Rothschild was a major fund raiser for Hillary Clinton's 2008 presidential bid, she transferred her support to Republican candidate John McCain when Barack Obama beat Clinton, becoming a minor celebrity on cable television at the time for attacking Obama in a series of interviews.[5]
On June 22, 2011, she hosted a fundraiser for Jon Huntsman Jr.'s presidential campaign, an event originally planned to support Mitt Romney before she had a change of heart in the early summer of 2011.[11] In the summer of 2016, she hosted a fundraiser for Hillary Clinton's 2016 presidential campaign.[12]
Rothschild co-chaired/founded the day-long Conference of Inclusive Capitalism in London on May 27, 2014,[13] with the aim of adjusting the working of the capitalist system to work for more people and included an opening address by Prince Charles and guest speaker Bill Clinton.[14] The second conference also took place in London on June 26, 2015
Rothschild is actively involved in policy and social issues, including micro-finance and women's rights. In 2006, she was appointed as a member of the UN Advisors Group on Inclusive Financial Services.[citation needed] She serves as Chairman of the Board for the American Patrons of the Tate Gallery, FAI, and the International Advisory Board of Columbia University School of Law.[8] In addition, she serves as a Trustee of the ERANDA Foundation (a Rothschild family foundation), the Outward Bound Trust, the Alfred Herrhausen Society of International Dialogue of Deutsche Bank and the Global Commercial Microfinance Consortium Advisory Board of Deutsche Bank.[8] She also sits on the board of the McCain Institute.[15]
She is a member of the Council on Foreign Relations (USA), Chatham House (UK), the Institute for Strategic Studies (UK), the International Advisory Council of Asia House (UK), and the Foreign Policy Association (USA).[8]