DING DING DING!
Bad timing?
Following the death of Manuel I in 1180, his widow, the Latin princess Maria of Antioch, acted as regent to her infant son Alexios II Komnenos. Her regency was notorious for the favoritism shown to Latin merchants and the big aristocratic land-owners, and was overthrown in April 1182 by Andronikos I Komnenos, who entered the city in a wave of popular support.[1][12] Almost immediately, the celebrations spilled over into violence towards the hated Latins, and after entering the city's Latin quarter a mob began attacking the inhabitants.[4]
Many had anticipated the events and escaped by sea.[3] The ensuing massacre was indiscriminate: neither women nor children were spared, and Latin patients lying in hospital beds were murdered.[4] Houses, churches, and charities were looted.[4] Latin clergymen received special attention, and Cardinal John, the papal legate, was beheaded and his head was dragged through the streets at the tail of a dog.[3][13]
Although Andronikos himself had no particular anti-Latin attitude, he allowed the massacre to proceed unchecked.[14] A few years later, Andronikos I himself was deposed and handed over to the mob of Constantinople citizenry, and was tortured and summarily executed in the Hippodrome by Latin soldiers.