>>119145 Ghost Ezra (T.me) Phase I trial begins for Moderna's mRNA HIV vaccine
Since AIDS was first identified, over 36 million deaths have been attributed to it worldwide.
The Phase I Trial for an mRNA HIV (Human immunodeficiency virus) vaccine developed by Moderna and the nonprofit scientific research organization IAVI began on Thursday as the first participant was administered a dose of the experimental vaccine, according to Moderna.
The immunogens in the experimental vaccine were developed by IAVI and Scripps Research and will be delivered through Moderna's mRNA technology.
The vaccine design approach is known as germline targeting, a method that sees a person's unmutated white blood cells being prompted to develop into producing broadly neutralizing antibodies (bnAb), which have been proven to neutralize a broad range of HIV variants.
The induction of bnAbs is widely considered to be the goal of HIV vaccination, Moderna has stated, and the phase I trial is the first step in the process.
HIV/AIDS was first discovered in 1981 and was first reported on in a gay newspaper, The New York Native, on May 1 of that same year. HIV was transferred from non-human primates (primarily chimpanzees) to humans in west-central Africa in the early-to-mid 20th century in a process known as zoonosis.
https://www.jpost.com/breaking-news/article-695008
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