https://digital.ahrq.gov/sites/default/files/docs/publication/r18hs017045-lazarus-final-report-2011.pdf
2011: Lazarus Final Report
Adverse events from drugs and vaccines are common, but underreported.
Although 25% of ambulatory patients experience an adverse drug event,less than 0.3% of all adverse drug events and 1-13% of serious events are reportedto the Food and Drug Administration (FDA).
Likewise, fewer than 1% of vaccine adverse events are reported.Low reporting rates preclude or slow the identification of “problem” drugs and vaccines that endanger public health.
New surveillance methods for drug and vaccine adverse effects are needed.