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https://www.dailymail.co.uk/news/article-10266585/AstraZeneca-uncovers-trigger-blood-clots-jab.html
AstraZeneca uncovers what's triggering blood clots after its jab: Vaccine acts like a magnet and attracts platelets which body mistakes for a threat and attacks
AstraZeneca uncovers what's triggering blood clots after its jab: Vaccine acts like a magnet and attracts platelets which body mistakes for a threat and attacks
A new study has found possible link to rare jab blood-clots which has been connected to the death 73 Britons
Scientists found the virus used in the jab attracts a protein in the blood, called platelet factor 4, like a magnet
In a case of 'mistaken identity' the body's immune system then attacks this cluster, triggering the blood clots
Scientists believe they have solved the mystery behind the extremely rare blood clots caused by the Oxford-AstraZeneca vaccine.
A team of international experts, involving researchers from AstraZeneca, say that in a very small number of cases — about one in 100,000 in the UK — the vaccine can set off a chain reaction which leads to the body confusing its own blood platelets for fragments of virus.
The British-made vaccine is thought to have saved about a million lives from Covid and was the backbone of the UK's initial rollout earlier in the year, helping it to become the most vaccinated country in the West.
But concerns about clots saw its restriction in under-40s in the UK in spring and led Pfizer and Moderna's vaccines being favoured for young adults and as boosters. It was outright banned in many European countries and the US decided not to purchase a single dose.
The UK Government gave an emergency grant to a team of scientists led by Cardiff University to investigate the clotting phenomenon.
They found that the shell of the vector vaccine — the weakened cold virus used to teach cells how to neutralise Covid — sometimes acts like a magnet and attracts platelets, a protein found in the blood.
For reasons the scientists are still probing, the body then mistakes these platelets as a threat and produces antibodies to fight them. The combination of the platelets and the antibodies clumping together leads to the formation of dangerous blood clots.
But they stress this is extremely rare, with only 426 cases in the UK recorded the cases so far out of about 50million doses of the vaccine, equivalent to less than one in 100,000. The side effect has been linked to 73 deaths in the UK.
Researchers are now doing further work to learn more about the process that causes these clots and if the vaccine can be tweaked to reduce this risk.
In a very small number of cases — about one in 100,000 in the UK — the vaccine can set off a chain reaction which leads to the body confusing its own blood platelets for fragments of virus. The shell of the vector vaccine — the weakened cold virus used to teach cells how to neutralise Covid — sometimes acts like a magnet and attracts platelets, a protein found in the blood. For reasons the scientists are still probing, the body then mistakes these clumps as a threat and produces antibodies to fight them. The combination of the platelets and the antibodies clumping together leads to the formation of dangerous blood clots
The Oxford University-AstraZeneca jab is a adenovirus vaccine, meaning it contains a genetically altered virus, in this case chimpanzee cold virus, modified to be incapable of infecting the human body.
The vaccine works by using the chimpanzee cold virus to deliver a portion of the Covid virus's genetic code which the body then learns to recognise and prepare itself for a real infection from the virus.
Adenovirus technology is also used in the single dose Johnson and Johnson Covid vaccine which as also been linked to a small number of life threatening blood clot cases. The UK has donated the 20million doses of the Johnson and Johnson it ordered to the COVAX scheme — the UN's vaccine sharing programme.
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