>>90705

we nose you lubs us when we cutz up n sheitz

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2012 Benghazi attacks, assaults on a U.S. diplomatic compound and a nearby CIA annex in the city of Benghazi, Libya, onSeptember 11–12, 2012,which resulted in the deaths of four Americans, including the U.S. ambassador to Libya—the first violent death of a U.S. ambassador since 1988. The incident sparked controversy and ignited a political firestorm in the United States.

REMEMBER BENGHAZI

NY Hospital Will Stop Delivering Babies as Maternity Workers Resign Over Vaccine Mandate

September 12, 2021

A hospital in Upstate New York won’t have the capacity to deliver babies after six employees in its maternity ward resigned instead of taking the COVID-19 vaccine as part of an executive order handed down by former Gov. Andrew Cuomo several weeks ago.

Lewis County General Hospital in Lowville said that it will work with state officials to ensure that the maternity unit doesn’t shut down permanently, officials said, reported WWNY-TV. Six employees who were employed in the unit resigned, while seven more who are apparently not vaccinated are undecided, Lewis County Health System Chief Executive Officer Gerald Cayer said.

Due to the staffing shortage, the hospital won’t be able to deliver newborns, Cayer said.

“If we can pause the service and now focus on recruiting nurses who are vaccinated, we will be able to reengage in delivering babies here in Lewis County,” Cayer said at a news conference on Sept. 10.

About 165 hospital employees have not yet been vaccinated against COVID-19, the disease caused by the CCP (Chinese Communist Party) virus, Cayer said. That’s about 27 percent of the workforce, he said.

“Our hope is as we get closer (to the deadline), the numbers will increase of individuals who are vaccinated, fewer individuals will leave and maybe, with a little luck, some of those who have resigned will reconsider,” Cayer said. “We are not alone. There are thousands of positions that are open north of the Thruway (a highway system spanning Upstate New York) and now we have a challenge to work through, you know, with the vaccination mandate.”

In August, Cuomo, a Democrat who resigned over alleged inappropriate behavior with staffers, issued an order that all healthcare workers in New York state have to get their first COVID-19 shot by Sept. 27. And last week, President Joe Biden issued an announcement saying that healthcare workers at facilities that receive Medicaid or Medicare funding have to get vaccinated with no exceptions, with officials estimating that 50,000 such employees would be impacted by the mandate.

Hospital workers in California, Tennessee, and Texas have demonstrated against recent vaccine mandates. In June, a number of employees at Houston Methodist hospital in Texas walked out of their shifts to protest the company’s vaccine mandate.

Biden’s announcement also targeted more than 80 million workers who are employed at companies with 100 workers or more, saying that these employees have to either get weekly testing for the CCP virus or the vaccine. Although few details about the plan have been released about how it would be enforced, some officials said that harsh fines would be imposed if the workers don’t adhere to the mandate.

The Epoch Times has contacted Lewis County General Hospital for additional comment.

https://www.theepochtimes.com/ny-hospital-will-stop-delivering-babies-as-maternity-workers-resign-over-vaccine-mandate_3993409.html

>>90709

read up on biochemical mediation

lemme know

>>90711

anons NEVER forget

we gotz it all

MI gotz it all

mofos gonna pay

all of em

>>90716

what is the pH of milk?

>>90719

have you ever had fresh warm milk from the cow? I have, diff taste and safe right out of the cow

since we can't all have cows it needs to be pasteurized to bottle, ship and sell

>>90713

>>90715

Bet yo ass never tap

kek

Never forget:

Chris Stevens

Sean Smith

Glen Doherty

Tyrone Woods

>>90723

Abstract

Protons dissociated from organic acids in cells are partly buffered. If not, they are transported to the extracellular fluid through the plasma membrane and buffered in circulation or excreted in urine and expiration gas. Several transporters including monocarboxylate transporters and Na+/H+ exchanger play an important role in uptake and output of protons across plasma membranes in cells of metabolic tissues including skeletal muscle and the liver. They also contribute to maintenance of the physiological pH of body fluid. Therefore, impairment of these transporters causes dysfunction of cells, diseases, and a decrease in physical performance associated with abnormal pH. Additionally, it is known that fluid pH in the interstitial space of metabolic tissues is easily changed due to little pH buffering capacitance in interstitial fluids and a reduction in the interstitial fluid pH may mediate the onset of insulin resistance unlike blood containing pH buffers such as Hb (hemoglobin) and albumin. In contrast, habitual exercise and dietary intervention regulate expression/activity of transporters and maintain body fluid pH, which could partly explain the positive effect of healthy lifestyle on disease prognosis.

Go to:

1. Introduction

Body fluid pH is determined by the content of protons (H+) generated from organic acids produced in living cells. Lactic acid (lactate−/H+) is a typical proton source and is involved in the regulation of physiological pH. In metabolic tissues such as skeletal muscle and adipose tissue, the glycolytic anaerobic metabolism mediates the conversion of glucose and glycogen into lactic acid. Because the pKa of lactic acid is 3.80, it is immediately dissociated into lactate (lactate−) and protons under physiological conditions, resulting in reduced intracellular pH. Pyruvic acid (pyruvate−/H+), an intermediate metabolite in the glycolytic system, is also a source of protons, although it generates much less protons compared to lactic acid. In addition, metabolites such as ketone bodies also act as proton sources. Beta-hydroxybutyric acid (beta-hydroxybutyrate−/H+), a typical ketone body, is generated as a result of fatty acid metabolism in the liver and is also dissociated into beta-hydroxybutyrate anions and protons, leading to the reduction of intracellular pH.

The intracellular pH in most living cells is alkaline compared to the pH generated by protons that are transported passively through the plasma membrane by electrochemical forces. In addition to buffering systems such as the bicarbonate-carbonate system, protein-proton binding, and phosphoric acid, several membrane transporters are responsible for proton removal from the cytosol and play important roles in maintaining the alkaline pH in cells (Figure 1). In most mammalian cells, H+-monocarboxylate cotransporters (MCTs) participate in the transport of monocarboxylic acids such as lactate, pyruvate, beta-hydroxybutyrate, and acetoacetate across the cellular membrane by cotransporting protons and monocarboxylate anions [1–3]. Other transporters such as the Na+/H+ exchanger (NHE) and bicarbonate-dependent exchanger also contribute to proton extrusion from the cytosol to the extracellular space [4, 5]. This review focuses on the critical role of the membrane transport system of protons in regulation of intracellular and extracellular fluid pH and its importance in maintaining physiological homeostasis and preventing diseases development.

An external file that holds a picture, illustration, etc. Object name is BMRI2014-598986.001.jpg

>>90726

1. Proton Transport across the Plasma Membrane in pH Regulation

Regulation of body fluid pH is one of the most important physiological functions of homeostasis, because activity of most chemical reactions via enzyme proteins is dependent on fluid pH. To maintain homeostasis of body fluid pH, various buffering systems are utilized in addition to proton excretion from the cytosol to the extracellular space and ultimately outside of the body. However, if production of organic acid is elevated or the buffering and excretion systems are impaired, body fluid turns acidic, leading to abnormal conditions. A typical example is elevation of lactic acid production in skeletal muscle in response to strenuous exercise, which leads to body fluid acidosis, preventing muscle contraction [6, 7]. Proton transport across the plasma membrane of muscle cells is important for maintaining the appropriate intracellular pH. Skeletal muscle is a major metabolic organ that generates acids, in particular during contraction. Strenuous muscle contractions can cause a drastic reduction in intramuscular pH to −6.5 with accumulation of more than 40 mM lactate [6–8], regardless of cellular buffering capacity. Several studies have shown that intracellular pH is reduced during muscle contraction and has a delayed recovery to basal conditions during the recovery phase in the absence of proton transporters [9]. This delay suggests that proton transporters play a key role in maintaining pH homeostasis. Indeed, the function of proton transporters is involved in the capacity for pH maintenance [9, 10]. In particular, over 80% of intracellular proton is transported through lactate cotransport in contracting muscle, although remaining parts are transported through NHE and bicarbonate-depending transport [8, 11]. The liver, another organ that is closely associated with the metabolism of organic acids, generates ketone bodies (i.e., acetoacetic and β-hydroxybutyric acids), metabolizes lipids, and converts lactate to glucose via gluconeogenesis. Therefore, this organ generates acidic conditions [12–14] and intracellular pH should be maintained by proton extrusion along with buffering function.

MCTs, a part of the solute carrier (SLC) 16 that contains 14 members in total, play a crucial role in proton transport across the plasma membrane by cotransporting monocarboxylates. Each isoform has different transport kinetics and is specifically located on a particular subcellular site. It has been shown that MCT1–MCT4 transport aliphatic monocarboxylates such as lactate, pyruvate, and ketone bodies [2] and that the direction of transport across the plasma membrane in a 1 : 1 manner is determined by the concentration gradients of protons and monocarboxylate both inside and outside of the cell [15–17]. Thus, these isoforms play important roles in proton transport maintaining intracellular pH. In particular, the expression of two MCT isoforms (MCT1 and MCT4) is associated with lactate disposal in muscles. MCT1 is highly expressed and located in both the sarcolemmal and the mitochondrial membranes of oxidative muscles [18–20]; on the other hand, MCT4 is predominantly located on the plasma membrane of glycolytic muscle and is assumed to contribute to lactate efflux [19, 21]. In contrast, MCT2 is mainly located on the membranes of liver cells and contributes to the extrusion of ketone bodies [22]. Other members of the family have different substrate specificities. For example, MCT6 has been shown to transport bumetanide, a diuretic drug [23], MCT 8 acts as a thyroid hormone transporter [24], MCT9 is a potential carnitine extrusion transporter [25], and MCT10 is identified as a low-affinity transporter of aromatic amino acids along with iodothyronines [26]. In addition, NHE is known as another major proton transporter that plays an important role in intracellular pH homeostasis by exchanging intracellular proton with extracellular Na+ using the chemical gradient between intra- and extracellular Na+ concentrations [4, 27]. Currently, 10 isoforms are known to exist in mammals. NHE1–NHE5 are located on the plasma membrane of their specific tissues, while NHE6–NHE9 are located on the membrane of subcellular organelles [27–29]. In particular, NHE1 has been recognized as a ubiquitous isoform and plays an important role in maintaining homeostasis in metabolic organs.

Proton transport across the plasma membrane is important for maintenance of intracellular and extracellular fluid pH. In particular, proton excretion and bicarbonate reabsorption are recognized as important function of renal tubules. Proton excretion into urine is mainly mediated by both proton-ATPase and NHE3 located on the apical plasma membrane of the proximal convoluted tubule participating in approximately 80% of bicarbonate reabsorption occurring in the whole kidney, acting as the major buffering system in blood [30, 31], which has also pH buffers such as Hb (hemoglobin) and albumin. Bicarbonate reacts with protons via catalytic carbonic anhydrase on the apical membrane and generates CO2. Then, it is transported into the blood by sodium-bicarbonate cotransporters on the basolateral side [32].

>>90727

1. pH Disturbance and Disease Development

The normal physiological pH of mammalian arterial blood is strictly maintained at 7.40; blood has pH buffers such as Hb (hemoglobin) and albumin. A decrease of more than 0.05 units from the normal pH results in acidosis. The body fluids of diabetic patients are chronically acidic and exhibit characteristic ketoacidosis caused by an increased level of ketone bodies in the blood [33, 34]. Insulin resistance in metabolic tissues such as skeletal muscle, adipose tissue, and the liver accelerates the utilization of lipids as an energy substrate instead of glucose. Excess lipolysis caused by impaired glucose metabolism leads to free fatty acids in circulation, which facilitate hepatic gluconeogenesis by the oxidation of fatty acids resulting in large quantities of ketone bodies. This further accelerates proton overloads, leading to the metabolic ketoacidosis found in diabetic patients. Such acidic conditions prevent the activity of metabolic enzymes such as phosphofructokinase and further accelerate the progression of pathological conditions [33–35]. Acidic conditions can also result in physical fatigue of diabetic patients. Therefore, maintaining normal pH is important for physiological homeostasis.

It has been suggested that loss of function of MCTs causes a change of body fluid pH. Several point mutations of the MCT gene have been shown to affect both specificity and transport activity. The spontaneously occurring mutation of arginine 306 to threonine in domain 8 of MCT1 resulted in reduced transport activity [36]. In addition, it has been shown that subjects who have mutations in MCT1 cDNA have drastically lower transport rates and a delayed decline of blood lactate after exercise [37, 38]. Healthy subjects feel severe chest pain and muscle cramping after strenuous exercise, along with a defect in lactate efflux from muscle. Furthermore, many amino acid differences that are not attributable to polymorphisms are found in MCT1 obtained from muscle tissues in these subjects [37, 39]; thus, mutations in MCT1 are related to physical fatigue and exercise performance. MCT dysfunction may lead to metabolic disorder. Indeed, lower level expression of MCT1 and MCT4 is found in the skeletal muscle of obese rats compared to normal rats [40]. In addition, the activity of lactate transport in muscle is also decreased by both denervation and aging [41, 42]. A significant negative correlation between the level of circulating lactate and degree of insulin sensitivity is found in humans [43], suggesting that lower lactic acid disposal caused by reduction of MCT function is associated with insulin resistance.

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1. Interstitial Fluid pH and Disease Development

Body fluid acidosis could also contribute to the development of metabolic diseases. Our recent study indicates that before the development of diabetic symptoms the interstitial fluid pH in ascites and metabolic tissues of Otsuka Long-Evans Tokushima Fatty (OLETF) rats is lower than the normal pH (7.40) [44]. The buffering capacity is relatively high in the cytosol and blood but low in the interstitial fluid due to limited buffering factors such as proteins [45, 46]. Therefore, interstitial fluid pH in metabolic tissues easily changes (Figure 1) and may contribute to the onset of insulin resistance. We have shown the inhibitory effect of extracellular pH on the insulin signaling pathway in the L6 rat myotube. The phosphorylation level and binding affinity to insulin of insulin receptors were significantly diminished in media with low pH [47]. In addition, the levels of Akt phosphorylation, a downstream of the insulin receptor, are also decreased in low pH media, along with a reduction in glucose uptake. These in vitro observations support the hypothesis that lower extracellular pH may cause insulin resistance in skeletal muscle cells. Other studies [48–50] have suggested a close correlation between organic acid production and insulin sensitivity in both type 2 diabetes patients and healthy subjects. In a cross-sectional study of over 1,000 subjects [48], it has been demonstrated that body weight and waist circumference have a negative correlation with both insulin sensitivity and urine pH. Patients with metabolic syndrome have also reported a significantly lower pH of 24 h urine compared to the normal subjects and a negative correlation between the mean 24 h urine pH and the number of metabolic syndrome abnormalities [49, 50]. It has been suggested that lower levels of serum bicarbonate and higher levels of anion gap resulting from metabolic acidosis are associated with lower insulin sensitivity [51]. Hyperlactacidemia is found in patients with obesity and type 2 diabetes [43], which supports the strong relationship between acidic condition and insulin sensitivity. Even in healthy subjects, acids level could be an independent risk factor for the development of type 2 diabetes [52].

Insulin resistance is one of the major symptoms of metabolic disorders and is frequently associated with hypertension, high blood glucose levels, visceral obesity, and dyslipidemia. Insulin resistance also causes type 2 diabetes and plays a key role in developing cancer and cardiovascular disease. Thus, pH abnormalities can cause abnormal metabolic regulation in a predisease state. We recently found an observation that the interstitial pH around the hippocampus, an important region for memory [53], is lower in diabetic OLETF rats (26 weeks of age) than in normal Wistar rats [54]. It has been reported that diabetic patients have a high risk of developing dementia and Alzheimer's disease [55] and may experience defective memory functions. The insulin action is required for neuronal survival within the central nervous system [56]. Fluctuating glucose levels resulting from defective insulin have been suggested to lead to apoptosis, energy starvation, formation of neuritic plaques and neurofibrillary tangles, hallmark lesions of Alzheimer's disease, and altered acetylcholine levels in the hippocampus [57, 58]. Therefore, we indicate that maintenance of the interstitial fluid pH within the normal range or the recovery of the interstitial pH to the normal range could be one of the most important factors in developing molecular and cellular therapies for metabolic brain disorders.

>>90729

1. pH Regulation by Diet and Exercise Intervention

The maintenance of pH in metabolic organs is achieved through various regulatory systems. Physical exercise and appropriate diet contribute to pH homeostasis. Habitual exercise adaptively accelerates the entry of fatty acids both from the plasma into the muscle cell and from the cytosol into the mitochondria, while also enhancing Krebs cycle function in the resting state. Their actions are caused by elevation of activity and expression of related enzymes in skeletal muscles [59–61]. Since the energy consumed in muscle during exercise is mainly supplied by carbohydrates and lipids, the exercise-induced lipid utilization may decrease the energy obtained from carbohydrates, further decreasing the lactate/proton production, or lactic acidosis. In addition, circulating and intramuscular buffering capacities are improved via habitual exercise increasing proteins, amino acids, and phosphate [62–64]. Peripheral circulation is also improved through vasodilation caused as a physiological adaptation to exercise [65], which further facilitates the proton washout. In particular there is evidence suggesting that excretion of protons from the cytosol to the extracellular space or into circulation via transporters located on the plasma membrane contributes to the prevention of intracellular acidosis. It has been reported that exercise training increases the MCT1 and MCT4 levels in the skeletal and cardiac muscle of humans and animals [66–68]. Although the regulation of MCT expression levels is not clearly understood, it has been suggested that protein kinases A and B are involved in the regulation of MCT expression [69] as an adaptation mechanism, which may be mediated by an increase in lactate movement across the membrane. In addition, our recent study has reported that MCT1 content in erythrocyte membranes is elevated by exercise training in rats [70, 71]. A proportion of the lactate released from skeletal muscles into the plasma is taken up by erythrocytes. The mature erythrocytes generate ATP only through the glycolytic pathway, since they have no mitochondrial machinery. Thus, erythrocytes cannot utilize lactate produced as a respiratory fuel and this necessitates the release of lactate into the plasma via MCT1 [72]. However, one of the most important roles of erythrocytes is to distribute released monocarboxylates by taking up monocarboxylates, since erythrocytes produce much less lactate than other tissues. Based on the results of our in vitro study, the skeletal muscle may be entirely dependent on MCT1-mediated lactate uptake by erythrocytes to maintain pH homeostasis [71]. In addition, there is a high correlation between the athletic performance of horses and their erythrocyte lactate concentrations after racing [73]. Therefore, efficient proton transport via MCTs induced by habitual exercise may contribute to the improvement of insulin sensitivity and muscle fatigue caused by lowered pH.

It is well known that adequate diet is important for controlling pathological conditions in patients with metabolic disorders. In addition, intervention studies in humans have reported that several bioactive factors included in foods such as antioxidants [74–77] and n-3 unsaturated fatty acids [78, 79] improve energy metabolism. Additional factors such as carotenoids, alpha lipoic acids, amino acids/peptides, and minerals may also offer preventive or therapeutic effects to combat hyperglycemia and several animal and culture studies have demonstrated their efficacy in improving insulin sensitivity [80–84]. The effects of these nutrients are only beneficial when administered in combination. In contrast to the successful application of dietary approaches or combined nutrients [85–87], various types of intervention studies using single nutrients have failed to clarify their beneficial action on cardiovascular risk and insulin resistance [88, 89]. Therefore, administration of multiple nutrients is considered more effective when compared to administration of a single bioactive factor. Propolis, a natural product derived from the plant resins collected by honeybees, contains various types of compounds including polyphenols, phenolic aldehydes, sesquiterpene quinones, coumarins, amino acids, steroids, and inorganic compounds [90] and has been reported to reduce the metabolic defects caused by abnormal blood glucose and insulin in young (18 weeks of age) OLETF rats [42] characterized by hyperphagia, obesity, decreased glucose infusion rate in a euglycemic clamp at 16–18 weeks of age, hyperinsulinemia around 25 weeks of age responding to an intravenous glucose infusion, and developing type 2 diabetes [91, 92]. Thus, our study indicates that propolis has a beneficial and preventive action on type 2 diabetes mellitus at early stages developing insulin resistance. Further, we have obtained evidence that intake of propolis elevates the pH of ascites and metabolic tissues compared with normal diet, indicating that dietary propolis diminishes production of organic acids or increases buffering capacity in those tissues. Therefore, propolis may be a useful compound to improve insulin sensitivity via prevention of metabolic acidosis. The molecular mechanism of how propolis improves interstitial pH is unclear, and we should strive to better understand the mechanism of this bioactive supplement.

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1. Conclusion

Membrane transport of protons is required for preventing acidic states of body fluid, maintaining physical performance, and improving metabolic impairments. In contrast to the intracellular and blood pH, interstitial fluid pH can easily be reduced by acid stress. This can disturb homeostasis of the intracellular metabolism, leading to the development of metabolic diseases. However, detailed mechanisms including the involvement of membrane transport of protons responsible for the reduction of interstitial fluid pH are unknown. In addition, activity and expression of proton transporters such as MCT and NHE are easily altered by various changes in the cell environment. More studies are required to examine the detailed regulatory mechanisms of proton transporters, including gene expression, protein modification, and membrane trafficking, in addition to their contributions to metabolic homeostasis.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4180894/

>>90725

this recall vote will trigger CA audit, watch

it will be cleaned up

tarp is set

trust the flan

stay clam

>>90735

cousins took me to see Beach Blanket Bingo

was pretty young

they all got in big trouble for it

I had no idea

kek

IT IS COMING AND NOTHING CAN STOP IT

US defaults on National Debt cuz Congress unable to raise the debt limit

Shit gonna hit the fan like you never ever seen before in your life

will make new budget tough

bout fuggen time they had to cut they budgets, like ebbudy else

>>90739

They had like 4-5 kids didn't they

fuzzy history for me

remember seeing here in WC before her death

MS is tough to live with

>>90742

took care of a family

daughter was dx with MS

at same age younger son dx ALS

they say there is no familial correlation

muh ass

them genes ain't right

demyelination

ALS is a killer

moar so than MS

#580

>>90725 Wonky Voting in California Recall Election

>>90708, >>90710 NY Hospital Will Stop Delivering Babies as Maternity Workers Resign Over Vaccine Mandate

>>90707, >>90724 REMEMBER BENGHAZI The Other 911

#580

gotz sum IRL

back pretty quick

lemm know

‘Flying dragon’ fossil discovered in Chilean desert

Scientists in Chile have discovered the fossil of a so-called “flying dragon” dinosaur — the first of its kind found in the southern hemisphere.

The Jurassic-era creature, an early pterosaur, was found by paleontologists in Chile’s Atacama Desert.

The “dragon,” which roamed the earth 160 million years ago, has a long pointed tail, wings and sharp, protruding pointed teeth.

The remains, previously only ever found in North America, were unearthed by Osvaldo Rojas, director of the Atacama Desert Museum of Natural History and Culture.

The discovery suggests migration of the species between North and South America which are believed to have been linked in a supercontinent called Gondwana.

“This shows the distribution of the animals in this group was wider than what was known up to now,” Jhonatan Alarcon, a University of Chile scientist who led the investigation, told Reuters.

View of an Altiplano salt flat and lake in the Atacama Desert, Chile near the border with Argentina, South America

”There are pterosaurs of this group also in Cuba, which apparently were coastal animals, so most likely they have migrated between the North and the South or maybe they came once and stayed, we don’t know,” Alarcon said.

The Atacama Desert has become a hotspot for fossil discoveries. The barren, martian-looking landscape was submerged by sea waters in prehistoric times.

Detail of the discovery were published in the journal Acta Palaeontologica Polonica.

https://nypost.com/2021/09/12/flying-dragon-fossil-discovered-in-chilean-desert/?utm_medium=SocialFlow&utm_source=NYPTwitter&utm_campaign=SocialFlow

(President Trump calls America to 21 days of Prayer at #LetUsWorship)

https://www.youtube.com/watch?v=wvRu8-RN07s&t=438s

>>90746

#2903

Q !!mG7VJxZNCI 02/26/2019 18:49:44 ID: 1e2b4e

Archive Bread/Post Links: 5401736 / 5402061

Direct Link: 5402061

Anonymous 02/26/2019 18:41:14 ID:67117c

Archive Bread/Post Links: 5401736 / 5401939

Direct Link: 5401939

Feeling like Anons in US will be up late tonight following POTUS/Q in Vietnam.

>>5401939

It's going to be HISTORIC!

Planned long ago.

[-21]

Within the next 21 days BIG BIG BIG HAPPENINGS are going to take place.

Q

>>90749

In case anyone didnt' think death panels are real

be advised

politics has taken over medicine, again

45 stopped it once

heard his speech early 17 that did so

theY've redoubled their efforts

take care of your fam

>>90752

Poor Joe Biden.

So out to lunch and clueless.

During his stop in Shanksville, Pennsylvania on Saturday on the 20th Anniversary of the 9-11 Islamist attacks on America he decided to take a photo with a group of children. Joe loves the kids.

His handlers didn’t even notice these were based MAGA kids in pro-Trump T-shirts.