Virus inactivation under the photodynamic effect of phthalocyanine zinc(II) complexes
https://pubmed.ncbi.nlm.nih.gov/27845890/
Abstract
Various metal phthalocyanines have been studied for their capacity for photodynamic effects on viruses. Two newly synthesized water-soluble phthalocyanine Zn(II) complexes with different charges, cationic methylpyridyloxy-substituted Zn(II)- phthalocyanine (ZnPcMe) and anionic sulfophenoxy-substituted Zn(II)-phthalocyanine (ZnPcS), were used for photoinactivation of two DNA-containing enveloped viruses (herpes simplex virus type 1 and vaccinia virus), two RNA-containing enveloped viruses (bovine viral diarrhea virus and Newcastle disease virus) and two nude viruses (the enterovirus Coxsackie B1, a RNA-containing virus, and human adenovirus 5, a DNA virus). These two differently charged phthalocyanine complexes showed an identical marked virucidal effect against herpes simplex virus type 1, which was one and the same at an irradiation lasting 5 or 20 min (Δlog=3.0 and 4.0, respectively). Towards vaccinia virus this effect was lower, Δlog=1.8 under the effect of ZnPcMe and 2.0 for ZnPcS. Bovine viral diarrhea virus manifested a moderate sensitivity to ZnPcMe (Δlog=1.8) and a pronounced one to ZnPcS at 5- and 20-min irradiation (Δlog=5.8 and 5.3, respectively). The complexes were unable to inactivate Newcastle disease virus, Coxsackievirus B1 and human adenovirus type 5.
The 6 page paper is attached as PDF
>https://twitter.com/BBCArabic/status/1290771289939075073
Maryam Toumi
An alarm can be heard going off before Ms Toumi picks herself back up and lifts the camera from the floor.
Officials said they expected the death toll - already at 78 - to rise further after Tuesday's blast as emergency workers dug through rubble to rescue people and remove the dead.
That was fireworks going off in the fireworks factory. All the different chemicals mixed in the air above the port.
It could well have been a small nuke that blew up the sodium nitrate warehouse to get things started.
But when the big boom came, it was because uncombusted materials like diesel vapors were mixed with the nitrate cloud
Creating an ANFO fuel-air explosion.
Targeting Glutamine Induces Apoptosis: A Cancer Therapy Approach
https://www.mdpi.com/1422-0067/16/9/22830/htm
Abstract
Glutamine metabolism has been proved to be dysregulated in many cancer cells, and is essential for proliferation of most cancer cells, which makes glutamine an appealing target for cancer therapy. In order to be well used by cells, glutamine must be transported to cells by specific transporters and converted to glutamate by glutaminase. There are currently several drugs that target glutaminase under development or clinical trials. Also, glutamine metabolism restriction has been proved to be effective in inhibiting tumor growth both in vivo and vitro through inducing apoptosis, growth arrest and/or autophagy. Here, we review recent researches about glutamine metabolism in cancer, and cell death induced by targeting glutamine, and their potential roles in cancer therapy.
This is about how Green Tea with EGCG can kill cancer cells
Glutamine and cancer: cell biology, physiology, and clinical opportunities
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3754270/
Abstract
Glutamine is an abundant and versatile nutrient that participates in energy formation, redox homeostasis, macromolecular synthesis, and signaling in cancer cells. These characteristics make glutamine metabolism an appealing target for new clinical strategies to detect, monitor, and treat cancer. Here we review the metabolic functions of glutamine as a super nutrient and the surprising roles of glutamine in supporting the biological hallmarks of malignancy. We also review recent efforts in imaging and therapeutics to exploit tumor cell glutamine dependence, discuss some of the challenges in this arena, and suggest a disease-focused paradigm to deploy these emerging approaches.
Epstein Victim's Story Buried By Media & FBI — The Political Vigilante
Graham talks with Whitney Webb about her phone call with, Epstein survivor, Maria Farmer.
Dirty Republicans
Dirty Democrats