Remdesivir works. It does its job by interfering with the mechanism that the retroviruses use to replicate. Let's learn some more…

Remdesivir explained – what makes this drug work against viruses?

https://theconversation.com/remdesivir-explained-what-makes-this-drug-work-against-viruses-137751

With the FDA approving Gilead’s Remdesivir as an emergency use treatment for the most acute cases of COVID-19, many people are wondering what type of a drug it is.

Remdesivir is a member of one of the oldest and most important classes of drugs – known as nucleoside analogue. Currently there are more than 30 of these types of drugs that have been approved for use in treating viruses, cancers, parasites, as well as bacterial and fungal infections, with many more currently in clinical and preclinical trials.

I am a medicinal chemist who has worked in design and synthesis of these important drug treatments for over 30 years. I have written numerous reviews over the years about these drugs and their structure and function, and as a result have had many inquiries lately from friends, family and others not in the field asking me to explain what exactly is it about Remdesivir that makes it so effective, but also why it is so interesting. Understanding why means digging into the biochemistry of this class of drugs.

Fake genetic building blocks

The reason nucleoside analogues and a similar group called nucleotide analogues are so effective is that they resemble the naturally occurring molecules known as nucleosides – cytidine, thymidine, uridine, guanosine and adenosine. These are the essential building blocks for the DNA and RNA that carry our genetic information and play critical roles in our body’s biological processes.

Slight differences in the chemical structure of these analogues from naturally occurring compounds make them effective as drugs. If an organism like a virus incorporates a nucleoside analogue into its genetic material, rather than the real thing, even small changes to the structure of these building blocks prevent the regular chemistry from happening and ultimately foils the ability of the virus to replicate.

Very interesting. Because Zinc also disrupts the mechanism that retroviruses use to replicate. But Remdesivir has no Zinc. It's unusual component is Phosphorus

>>10217418

But wait a minute. Isn't there a connection between Zinc and Phosphorus? And affinity or antagonism? Maybe it's one of those love hate relationships…

DON’T FORGET ZINC WHEN APPLYING PHOSPHORUS TO YOUR FARM

https://www.cropnutrition.com/resource-library/dont-forget-zinc-when-applying-phosphorus-to-your-farm

Introduction

Phosphorus (P) fertilizer is often added to cropping systems to increase yield, but growers should not overlook the importance of micronutrients like Zinc (Zn). Understanding some of the nutrient interactions that affect nutrient availability can help with management decisions like fertilizer source. The interaction of P and Zn has been well researched and documented in the fields of soil chemistry and plant nutrition. For example, research shows that high rates of P fertilizer without adequate plant available Zn can reduce Zn uptake by the roots, induce Zn deficiency, and decrease plant growth and yield. When making decisions for a soil fertility program, it is important to consider some of the factors and situations that may cause P-Zn antagonism and how to best avoid or minimize those factors.

I'm curious what happens to all those medical personnel taking prophylactic HCQ with Zinc, when they catch COVID and then take Remdesivir. Will it work in the same way as a non-Zinc user?