Anonymous ID: 0989f2 Aug. 7, 2020, 10:16 p.m. No.10220483   🗄️.is 🔗kun   >>0502 >>0527 >>0657 >>0711 >>0729 >>0738 >>0786 >>0867 >>0893 >>1047 >>1116

Diluted blood plasma found to reverse aging in miceJune 15 2020

A new study by bioengineers at the University of California (UC), Berkeley has revealed an interesting new pathway in efforts to fight off the effects of aging. The team’s research has shown how diluting the blood plasma of older mice can have a strong rejuvenation effect on tissues and organs, by reducing the concentration of inflammatory proteins that typically increase with age.

 

The new research builds on a study published 15 years ago, where UC Berkeley scientists Irina and Michael Conboy found that when making conjoined twins of old and young mice so they shared blood and organs, they could reverse some of the effects of aging in the older animal. This prompted a lot of research into the proteins and molecules that could be contained in the younger mouse’s blood that might function as a “fountain of youth” and might possibly be harnessed to slow or reverse aging.

 

All these years later, the pair are still probing the mysteries of aging and the repercussions of their groundbreaking study, but are looking at it from a slightly different angle. The researchers have been investigating the idea that rather than using the proteins and molecules from young blood, perhaps the process of aging could be slowed by cleansing the old blood of its harmful proteins and molecules.

 

“We thought, ‘What if we had some neutral age blood, some blood that was not young or not old?’” says Michael Conboy. “We’ll do the exchange with that, and see if it still improves the old animal. That would mean that by diluting the bad stuff in the old blood, it made the animal better. And if the young animal got worse, then that would mean that that diluting the good stuff in the young animal made the young animal worse.”

 

The scientists explored this idea through experiments involving treated blood plasma, where part of the animal’s blood was substituted for a special solution made of basic ingredients in saline and the protein albumin, which replaces the lost albumin proteins in the extracted blood.

 

This neutral blood exchange, where half of the blood plasma in older mice was swapped out for the solution, was found to significantly improve their health. The rejuvenation effects on the brain, liver and muscles were the same or stronger than in the original experiments in 2005, while the procedure was found to have no ill health effects on younger mice.

 

Using proteomic analysis to study the blood plasma and its contents of proteins, the team found that the process acts like a “molecular reset button.” Following the exchange, the team observed lower concentrations of pro-inflammatory proteins that increase with age, while beneficial proteins including those that promote vascularization, where able to flourish.

 

he exchange of plasma in humans is already approved in the US for treatment of some autoimmune diseases, taking two to three hours and producing mild or zero side effects.The team is now in the process of drawing up clinical trials to explore the potential of these neutral blood exchanges in older people.

 

https://newatlas.com/medical/diluted-blood-plasma-reverse-aging-in-mice/

Anonymous ID: 0989f2 Aug. 7, 2020, 10:24 p.m. No.10220533   🗄️.is 🔗kun

>>10220502

Alan Wentnick JUNE 16, 2020 09:09 AM

My wife is age 79 she has seronegative mg

She has been undergoing plasma exchange twice every three weeks for the last few years with albumin. I have noticed a significant improvement in her physical and mental capabilities. This research confirms it.

 

Comment from under the plasma article.

https://newatlas.com/medical/diluted-blood-plasma-reverse-aging-in-mice/

Anonymous ID: 0989f2 Aug. 7, 2020, 10:59 p.m. No.10220749   🗄️.is 🔗kun   >>0786 >>0867 >>0893 >>1047 >>1116

Market For Blood Plasma From COVID-19 Survivors Heats Up

 

To avoid what Joyner described as a "range war" for COVID-19 plasma, he's spearheading an effort that calls for unprecedented collaboration to distribute separate streams of plasma among producers of therapies in a global market =estimated to reach $35.5 billion by 2023.

 

In Utah, John and Melanie Haering, who contracted COVID-19 aboard the ill-fated Diamond Princess cruise ship, received gift cards worth$800=. after making two donations apiece at a Takeda Pharmaceuticals' BioLife Plasma Services center.== BioLife runs several of the more than 800 paid-plasma collection sites in the U.S., part of an industry that produces plasma protein therapies used to treat rare, chronic conditions such as hemophilia and in medical emergencies.

 

"We don't view it as competition," said Chris Healey, president of corporate affairs at Grifols, a Spanish pharmaceutical company that has received nearly $13 million in funding from the U.S. Department of Defense to develop its own hyperimmune globulin product. "We're all pointed in the same direction."

 

One solution may be organizations such as Berrent's nonprofit Survivor Corps, which started in late March with a Facebook group that's grown to 42,000 members and now includes international partnerships and a pro bono advertising campaign, A Call to Arms.

 

Berrent has given plasma four times now, including to a biotech firm thatsent a phlebotomist to her home and gave her a $100 Amazon card for her trouble.

 

Survivor Corps aims to function as a "one-stop shop" for donors interested in giving COVID-19 plasma, Berrent said. And, she said, it also could serve as a single source for recruitment, freeing scientists in government, academia and industry to focus on finding answers, not scouting for survivors.

 

CSL has joined with Takeda, a Japanese pharmaceutical company, to lead the CoVIg-19 Plasma Alliance, a coalition of six companies developing a single, unbranded hyperimmune globulin product that could treat COVID-19.

 

"Free markets work beautifully in many, many situations," Berrent said. "During a global pandemic, during a time of crisis, we need collaboration and efficiency."

 

https://www.npr.org/sections/health-shots/2020/05/11/852354920/market-for-blood-plasma-from-covid-19-survivors-heats-up

 

Rather long article