Remdesivir works. It does its job by interfering with the mechanism that the retroviruses use to replicate. Let's learn some more…

Remdesivir explained – what makes this drug work against viruses?

https://theconversation.com/remdesivir-explained-what-makes-this-drug-work-against-viruses-137751

With the FDA approving Gilead’s Remdesivir as an emergency use treatment for the most acute cases of COVID-19, many people are wondering what type of a drug it is.

Remdesivir is a member of one of the oldest and most important classes of drugs – known as nucleoside analogue. Currently there are more than 30 of these types of drugs that have been approved for use in treating viruses, cancers, parasites, as well as bacterial and fungal infections, with many more currently in clinical and preclinical trials.

I am a medicinal chemist who has worked in design and synthesis of these important drug treatments for over 30 years. I have written numerous reviews over the years about these drugs and their structure and function, and as a result have had many inquiries lately from friends, family and others not in the field asking me to explain what exactly is it about Remdesivir that makes it so effective, but also why it is so interesting. Understanding why means digging into the biochemistry of this class of drugs.

Fake genetic building blocks

The reason nucleoside analogues and a similar group called nucleotide analogues are so effective is that they resemble the naturally occurring molecules known as nucleosides – cytidine, thymidine, uridine, guanosine and adenosine. These are the essential building blocks for the DNA and RNA that carry our genetic information and play critical roles in our body’s biological processes.

Slight differences in the chemical structure of these analogues from naturally occurring compounds make them effective as drugs. If an organism like a virus incorporates a nucleoside analogue into its genetic material, rather than the real thing, even small changes to the structure of these building blocks prevent the regular chemistry from happening and ultimately foils the ability of the virus to replicate.

Very interesting. Because Zinc also disrupts the mechanism that retroviruses use to replicate. But Remdesivir has no Zinc. It's unusual component is Phosphorus

>>10224313

DON’T FORGET ZINC WHEN APPLYING PHOSPHORUS TO YOUR FARM

https://www.cropnutrition.com/resource-library/dont-forget-zinc-when-applying-phosphorus-to-your-farm

Introduction

Phosphorus (P) fertilizer is often added to cropping systems to increase yield, but growers should not overlook the importance of micronutrients like Zinc (Zn). Understanding some of the nutrient interactions that affect nutrient availability can help with management decisions like fertilizer source. The interaction of P and Zn has been well researched and documented in the fields of soil chemistry and plant nutrition. For example, research shows that high rates of P fertilizer without adequate plant available Zn can reduce Zn uptake by the roots, induce Zn deficiency, and decrease plant growth and yield. When making decisions for a soil fertility program, it is important to consider some of the factors and situations that may cause P-Zn antagonism and how to best avoid or minimize those factors.

Causes of Negative P-Zn Interaction

Formation of Insoluble Zn-Phosphate Complexes

One of the primary causes of Zn deficiency in soils treated with high amounts of P fertilizer is its reaction with soluble Zn in the soil. This reaction produces insoluble Zn-phosphate complexes which influences the availability of Zn for plant uptake over time (Mortvedt, 1991). A potential outcome is a reduction of Zn availability leading to Zn deficiency and reduced plant growth.

>>10224339

What is it with Zinc and Phosphorus?

Everything seems to go better when they are around!!!

>>10224315

Florida Pharmacists Sounding the Alarm, Accuse PBMs of ‘Hijacking’ Health Care Spending

https://www.floridadaily.com/florida-pharmacists-sounding-the-alarm-accuse-pbms-of-hijacking-health-care-spending/

With Americans continuing to be impacted by the spiraling costs of health care, some neighborhood pharmacists across Florida have an idea to do something about the growing problem.

Pharmacists across Florida have banded together to push for reforms to add more transparency to Pharmacy Benefit Managers (PBMs) which, the pharmacists insist, are driving up costs.

PBMs originally came into existence to be a helpful “middle man” between pharmaceutical companies, insurers and local pharmacies. They were initially designed to control costs and negotiate savings which would allow pharmacists to spend more time advising customers, making deliveries when needed and working out payment arrangements for struggling patients.

But in recent years, the PBM process has grown into a full-blown, multi-billion-dollar industry.

As certain PBMs got bigger, they began gobbling up the smaller ones. Currently, a handful of PBMs control the overwhelming majority of the market nationwide. Many of these companies are also affiliated with their own pharmacy chains, including CVS and Walgreens.

Neighborhood pharmacies complain that they are getting drowned out by their larger rivals, leaving consumers have fewer choices and higher prices.

Florida is home to around 1,300 neighborhood pharmacies that employ more than 12,000 people. In 2017, they filled more than 78 million prescriptions for Florida patients. But they’re not the only ones adversely affected by PBMs.

Taxpayers, who support Medicaid, Medicare, and other government programs, pay the price when PBMs inflate prices, said Kevin Duane, a pharmacist at Panama Pharmacy in Jacksonville, the city’s oldest pharmacy.

High-phosphorus/zinc-free diet aggravates hypertension and cardiac dysfunction in a rat model of the metabolic syndrome

https://pubmed.ncbi.nlm.nih.gov/23932324/

Abstract

Background: Cardiac dysfunction is reported in patients with the metabolic syndrome. We assessed the effects of high-phosphorus and zinc-free diet on cardiovascular system in spontaneously hypertensive rats (SHR)/NDmcr-cp (SHR/cp), a rat model of the metabolic syndrome. We also investigated the effects of N-acetyl-L-cysteine (NAC), an antioxidant, on the development of cardiac dysfunction under such conditions.

Methods: Male SHR/cp and control [Wistar Kyoto (WKY)] rats were divided into three groups and fed control diet (P 0.3% w/w, Zn 0.2% w/w) or high-phosphorus and zinc-free (P 1.2% w/w, Zn 0.0% w/w) diet. The latter group was treated with either NAC (1.5 mg/g per day) or vehicle from 6 to 18 weeks of age (n=6 or 8 for each group).

Results: High-phosphate and zinc-free diet increased systolic blood pressure in both WKY and SHR/cp. Echocardiography showed that high-phosphate and zinc-free diet markedly reduced left ventricular systolic and diastolic function in SHR/cp. Histopathologically, the same diet induced severe myocardial fibrosis in SHR/cp, and this effect was prevented by NAC. Whereas treatment with NAC prevented diastolic dysfunction induced by the same diet in WKY, it only improved systolic function but not diastolic function in SHR/cp.

Conclusions: High-phosphate and zinc-free diet induced hypertension and cardiac dysfunction. These changes hamper the protective effects of NAC in the metabolic syndrome.

Summary: The present study showed that consumption of high-phosphorus and zinc-free diet increased the myocardial expression of connective tissue growth factor and reduced the expression of metallothionein, which enhanced the development of severe cardiac dysfunction in rats with the metabolic syndrome. The results suggest that the metabolic syndrome seems to aggravate cardiac dysfunction and hamper the protective effects of antioxidant, NAC.

The full 7 page paper is attached as a PDF

>>10224459

Zinc bioavailability in wheat grain in relation to phosphorus fertiliser, crop sequence and mycorrhizal fungi

https://onlinelibrary.wiley.com/doi/abs/10.1002/jsfa.3200

Abstract

BACKGROUND: While human diets are often deficient in zinc (Zn), the impacts of crop management on Zn in cereal grains are rarely examined. In this study the effect of phosphorus (P) fertiliser and crop sequence (wheat following canola, linola, fallow or pasture) on wheat grain Zn concentration and bioavailability for humans was investigated.

RESULTS: The Zn concentration of wheat grain decreased by 33–39% in response to P fertiliser. It was also 30–40% lower for crops following canola and fallow than for those following linola and pasture. P fertiliser decreased the colonisation of arbuscular mycorrhizal fungi (AMF) in wheat roots, and canola and fallow led to lower colonisation than linola and pasture. Since AMF are known to assist in soil uptake of immobile nutrients such as Zn, it is hypothesised that P fertiliser and crop sequence affected grain Zn concentration through AMF. P fertiliser also increased the concentrations of grain P by 17% and grain phytic acid (PA) by 19%, but had little effect on the concentrations of calcium (Ca), iron (Fe) and polyphenols. Other impacts of crop sequence were slightly higher concentrations in grain of P after pasture and Fe after canola. The bioavailability of grain Zn, as shown by the PA:Zn and Ca × PA:Zn molar ratios, mostly reflected Zn concentration and was low in all treatments. After milling, the PA:Zn molar ratio suggested low Zn bioavailability for flour from wheat grown with P fertiliser after canola or fallow.

CONCLUSION: Crop management can affect the bioavailability of Zn in wheat grain, with practices leading to high yields potentially leading to low Zn bioavailability.

The full 9 page paper is attached as a PDF

>>10224491

>>10224459

Why am I writing about Zinc and Phosphorus and Remdesivir?

Because Q taught us the importance of making connections and drawing the map.

The fact is that nothing in this world exists in isolation. Everything is a part of one of more systems, and you need to take aSystems Approachto understand things fully.

Perhaps there is a more sinister reason than money that leads the Cabal to promote a drug based on Phosphorus rather than treatments that use Zinc.

Rather than jumping on the bandwagon of hyping up HCQ, I prefer to dig deeper, to follow connections, and to learn the truth. There are no magic bullets, no special talismans like HCQ that will make everything better. HCQ is ineffective in many cases. It only helps people when it is given at an early stage in respiratory disease. Once people cannot breathe easily and go to the hospital,they need steroids or corticosteroids to stop and reverse the cytokine storm.

Sure, HCQ is good to use as a prophylactic, and if taken with Zinc it will help at the early stages. But so will Chloroquine and so will Artemisinin and especially good is the drugClioquinol which has 10 times the Zinc ionophore capability as HCQ.

Never forget who the enemy is and how they fight. When they see a breach in the wall, such are people learning about HCQ, they try to get us to focus all energy and attention on HCQ so that we think that is the goal and we have arrived at the end of our search. This is known as aLimited Hangoutwhich is a variation of the scapegoat or sacrificial lamb. After all, if we have Harvey Weinstein, then why should we go after the dozens of other Hollywood pedophiles?

Sorry, but I never stop. There is always a web of interconnections, and I want to map them as thoroughly as I can. Every time I go down a rathole, I learn more about recognizing ratholes. And even if I only hit paydirt a small percentage of the time, I know that I am creating a map for others to study from a 40000 foot view where they can see the patterns, and understand how the entire sordid business is constructed, and how all the parts support and protect each other.

It's a big and powerful enemy, but although he can run, and run and run, he cannot hide because his massive size leaves a trace everywhere he goes, and we can learn to follow those traces.

Read these three short intros, and the consider taking up the study of Systems Theory and Systems Engineering, because once the Cabal is defeated, there are still many big problems in the world that need fixing. That work will not be done in one or two generations. Look to the future.

>>10224583

You misstated.

The history books themselves will be wiped because since the creation of the American Historical Association, they are all fake.

New history books will be written, and every one of them will have an appendix about the Cabal and its plotting against history itself.

>>10224637

Because this search…

https://pubmed.ncbi.nlm.nih.gov/?term=zinc+quinine

gives only 67 results and most are not terribly relevant to respiratory viruses. Quinine is hard to get, basically you have to buy imported bark from Brazil and boil it down yourself. It is also more dangerous than HCQ.

There really is no point in using Quinine for anything other than making exotic gin and tonic occasionally.

>>10224734

Systems Theory applies because it helps you map out information and connections into a bigger picture.

For instance, HCQ can cure cancer. So it is more useful to people who have cancer than those with respiratory viruses.

But, HCQ is a malaria medicine, so when we look at other malaria medicines we find that they are also effective against COVID even Artemisinin which is chemically not related to quinine. And there is one medication,Clioquinolthat has 10 times the effect of HCQ as a Zinc ionophore.

Not to mention that the studies showing HCQ is ineffective all DO NOT USE ZINC while the ones showing that it is effective do use Zinc. This led Anons to discover that HCQ is a Zinc ionophore and that Zinc does prevent retroviruses including HIV from reproducing.

Now think back to Trump's statements about finding cures for Cancer, AIDS/HIV and Influenza, within a year. There is a far bigger picture here.

>>10224770

You are a liar with no source.

The only thing that deserved the title Magic Bullet in relation to COVID is a corticosteroid called Budesonide which takes effect within minutes, and reverses the cytokine storm symptoms within hours.

>>10224802

You are a LIAR

I'm beginning to believe that some fools have invested a lot of money in cinchona bark thinking that they can make big bucks.

Unfortunately, there is no proof that quinine is a zinc ionophore. Quinine treats malaria, a parasitic disease that is NOT caused by an RNA retrovirus and therefore does not reproduce in the same way.