Anonymous ID: e1dc14 Aug. 23, 2020, 9:39 a.m. No.10392810   🗄️.is 🔗kun   >>2819 >>2841 >>2981 >>3153 >>3291 >>3399 >>3469

>>10392787

Update on calcium pyrophosphate deposition

 

https://pubmed.ncbi.nlm.nih.gov/27586801/

 

Abstract

Calcium pyrophosphate crystal deposition (CPPD) associates with ageing, osteoarthritis (OA), uncommon metabolic diseases, mutations and polymorphisms in the ankylosis human gene (ANKH). CPPD is frequently polyarticular, occurs due to a generalised articular predisposition, and the association between CPPD and OA is joint specific, for example CPPD associates with knee OA, but not with hip OA. Other recently identified associations include knee malalignment (knee CC), low cortical BMD and soft-tissue calcification. CPPD is generally asymptomatic. A recent study reported that knees with OA plus CC at the index joint, or at distant joints (in absence of index joint CC), were more likely to have attrition. CPPD can cause acute CPP crystal arthritis, chronic CPP crystal inflammatory arthritis, and is frequently present in joints with OA. Joint aspiration remains the gold standard for diagnosing CPPD, although other promising techniques are emerging. Patients with polyarticular or young onset CPPD should be screened for underlying metabolic abnormalities, however, such testing can be unrewarding. The treatment of CPPD is symptomatic. Acute CPP crystal arthritis is treated with rest, local application of ice-packs, joint aspiration, colchicine and/or intra-articular corticosteroid injection (once infection is excluded). Colchicine, low-dose corticosteroids, hydroxychloroquine and radiosynovectomy are recommended for the treatment of chronic or recurrent acute CPP crystal arthritis. Recent RCTs did not confirm any benefit from methotrexate, and although there is increasing interest in the use of anti-IL1 agents for acute or chronic CPP crystal arthritis, their efficacy has not been formally examined. Unlike gout, currently there are no treatments to eliminate CPP crystal deposits.

Anonymous ID: e1dc14 Aug. 23, 2020, 9:47 a.m. No.10392867   🗄️.is 🔗kun   >>2981 >>2987 >>3153 >>3291 >>3399 >>3469

>>10392787

Updated Treatment for Calcium Pyrophosphate Deposition Disease: An Insight

 

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6411330/

 

Abstract

Calcium pyrophosphate disease (CPPD) is caused by the deposition of calcium pyrophosphate (CPP) crystals in the joint tissues, particularly fibrocartilage and hyaline cartilage. CPP crystals trigger inflammation, causing local articular tissue damage. Our review article below covers different aspects of CPPD. It discusses how CPPD can manifest as different kinds of arthritis, which may be symptomatic or asymptomatic. The metabolic and endocrine disease associations and routine investigations used in the diagnostic workup are briefly reviewed. Conventional and newer therapies for the treatment of CPPD are outlined. Overall, this extensive review would provide an updated insight to clinicians for evidence-based treatment of CPPD.

 

Updated treatment for calcium pyrophosphate deposition disease

CPPD: calcium pyrophosphate deposition disease, CPP: calcium pyrophosphate, COL: colchicine, HCQ: hydroxychloroquine, MTX: methotrexate, NSAID: nonsteroidal anti-inflammatory drug, PC: phosphocitrate, PolyP: polyphosphate

 

HCQ Effective in chronic CPPD-related arthropathies

 

Certain patients fail to respond to the above-mentioned conventional drugs. Hence, some disease-modifying antirheumatic drugs (DMARDs) such as methotrexate and hydroxychloroquine and other medicines have been considered to treat refractory cases of CPPD arthritis on the basis of randomized controlled trials conducted on small scale.

 

Hydroxychloroquine

 

Hydroxychloroquine (HCQ) is originally an anti-malarial drug that can be used as an adjuvant drug [24]. Several mechanisms of action have been suggested for HCQ in context to the treatment of CPPD, all of which signify its capability to immunomodulate and reduce inflammation. HCQ blocks the activity of T-cells, reduces the release of various cytokines (interleukin-1, interleukin-6 and tumor necrosis factor-alfa). It has also demonstrated to inhibit the activity of matrix metalloprotease in experimental animals. In a double-blinded, prospective six-month trial, HCQ was found to be beneficial specifically for chronic CPPD-related arthropathies [25].

 

  1. Hydroxychloroquine effectiveness in reducing symptoms of hand osteoarthritis (HERO): study protocol for a randomized controlled trial. Kingsbury S, Tharmanathan P, Adamson Adamson, et al. Trials. 2013;14:64. [PMC free article] [PubMed] [Google Scholar]

 

  1. Prospective 6-month, double-blind trial of hydroxychloroquine treatment of CPDD. Rothschild B, Yakubov LE. https://europepmc.org/abstract/med/9195122. Compr Ther. 1997;23:327–331. [PubMed] [Google Scholar]

Anonymous ID: e1dc14 Aug. 23, 2020, 10:01 a.m. No.10392963   🗄️.is 🔗kun   >>3007 >>3022

>>10392797

>>10392840

 

Using tonic water to cure viral disease will kill you

 

If the H2O poisoning from consuming 42 liters per day does not kill you first, then the pneumonia from neglecting your health will kill you.

 

But that's OK. Because the shills want you dead, so go ahead and COMMIT SUICIDE because you are a such a stupid MORON that your believe a sugary fizzy drink with Q on the label has magic in it.

 

This is not a joke. Tonic water has so little quinine in it that you need to drink 42 liters per day to get enough to cure a fever. Much safer to take Ibuprofen instead.

 

But if you want to cure COVID then you need the right things in the right combination.

 

First, take Vitamin D3 and Magnesium together. Read the attached pamphlet to understand why.

 

Second, take Vitamin C, 6000mg per day or more. Best to spread the tablets over the day, not all at once. This is a general antiviral, C is an antioxidant which gives your cells more oxygen to use in combatting the virus.

 

Third, take Zinc and a zinc ionophore. One of these three, listed in order from STRONGEST effect to weakest.

Green Tea with EGCG. Either supplement or brew it strong.

Quercetin supplements

Hydroxychloroquine. Even though it is the weakest Zinc ionophore it is good enough if taken early.

 

Fourth, CoQ10 100mg to 200mg and Selenium taken together. Take more CoQ10 if you are older or take statins.

 

Fifth, if you get sick and there is any sign of throat congestion or difficulty breathing, get to a doctor fast. You need steroids like Dexamethasone or corticosteroids like Budesonide or Prednisolone to reverse the cytokine storm that wants to kill you.

Anonymous ID: e1dc14 Aug. 23, 2020, 10:26 a.m. No.10393126   🗄️.is 🔗kun   >>3151

>>10393007

>>10393022

 

Both of these shills are promoting poisons that don't work or are harmful.

 

Hydrochloride is hydrochloric acid and will do terrible damage to your mouth, throat and stomach if it does not kill you.

 

Codeine is an opiate, just like oxycontin and fentanyl. We know who is behind opiate addiction and makes big bucks off that,

 

Go back to my message, not the PDF attachment from Dr. Mercola. Read it. Research any of the other items on pubmed. It is all public knowledge that you can research for yourself. Never trust someone you read on the Internet without researching it.