Building blocks of DNA and RNA could have appeared together before life began on Earth
http://www.spaceref.com/news/viewpr.html?pid=53877
Scientists for the first time have found strong evidence that RNA and DNA could have arisen from the same set of precursor molecules even before life evolved on Earth about four billion years ago.
The discovery, published April 1 in Nature Chemistry, suggests that the first living things on Earth may have used both RNA and DNA, as all cell-based life forms do now. In contrast, the prevailing scientific viewthe "RNA World" hypothesisis that early life forms were based purely on RNA, and only later evolved to make and use DNA.
"These new findings suggest that it may not be reasonable for chemists to be so heavily guided by the RNA World hypothesis in investigating the origins of life on Earth," says co-principal investigator Ramanarayanan Krishnamurthy, PhD, associate professor of chemistry at Scripps Research.
Krishnamurthy and his lab worked on the study with the lab of John Sutherland, DPhil, of the UK Medical Research Council's Laboratory of Molecular Biology at Cambridge, as part of the New York-based Simons Foundation's Collaboration on the Origins of Life.
RNA (ribonucleic acid) and DNA (deoxyribonucleic acid) are chemically very similar, but chemists have never been able to show how the one could have been converted to the other on the early Earth, except with the help of enzymes produced by early organisms. Due in part to this lack of a demonstrated pre-life or "pre-biotic" chemical path connecting RNA to DNA, researchers in this field have been inclined to think that the simpler, more versatile one, RNA, was the basis for the first life forms–or at least for an early stage of life prior to the emergence of DNA. RNA is able to store genetic information as DNA can, is able to catalyze biochemical reactions as protein enzymes can, and otherwise probably could have performed the basic biological tasks that would have been necessary in the first life forms.
Although origin-of-life researchers in recent decades have largely come to embrace the RNA World hypothesis, Sutherland, Krishnamurthy, Harvard's Jack Szostak and others have accumulated evidence that RNA and DNA may have arisen more or less all at once in the first life forms.
In a study published in 2017 for example, Krishnamurthy and colleagues at Scripps Research identified a compound that plausibly was present on the pre-biotic Earth and could have performed the crucial task of linking RNA building blocks into larger, chain-like RNA strands–and could have done the same for the building blocks of DNA and proteins.
In the new study, the scientists combined insights from that investigation with recent findings from Sutherland and his lab on a compound called thiouridine. The latter was likely present on Earth before life arose, and could have been a chemical precursor of the nucleoside building blocks of early RNAs. The team showed that in a few chemical-reaction steps, which plausibly could have occurred in a pre-biotic world, they could convert this precursor of an RNA building-block into a DNA building block–deoxyadenosine, which forms the letter "A" in the modern, four-letter DNA code. Alternatively they could convert thiouridine into deoxyribose, which is very closely related to deoxyadenosine and may also have been a precursor of early DNA building blocks.
The finding should make it easier for scientists to accept the possibility that DNA and RNA arose together and were included in the first life forms. Some researchers including Sutherland have suggested that RNA and DNA might even have been mixed together to make the first genes. No such organism is known to occur naturally now, but a recent paper by Scripps Research's Peter Schultz, PhD and colleagues described an engineered bacterium that can survive with genes made of an RNA/DNA mix.
Prebiotic precursors of the primordial RNA world in space: Detection of NH2OH
https://arxiv.org/abs/2008.00228
One of the proposed scenarios for the origin of life is the primordial RNA world, which considers that RNA molecules were likely responsible for the storage of genetic information and the catalysis of biochemical reactions in primitive cells, before the advent of proteins and DNA. In the last decade, experiments in the field of prebiotic chemistry have shown that RNA nucleotides can be synthesized from relatively simple molecular precursors, most of which have been found in space. An important exception is hydroxylamine, NH2OH, which, despite several observational attempts, it has not been detected in space yet. Here we present the first detection of NH2OH in the interstellar medium towards the quiescent molecular cloud G+0.693-0.027 located in the Galactic Center. We have targeted the three groups of transitions from the J=2−1, 3−2, and 4−3 rotational lines, detecting 5 transitions that are unblended or only slightly blended. The derived molecular abundance of NH2OH is (2.1±0.9)×10−10. From the comparison of the derived abundance of NH2OH and chemically related species, with those predicted by chemical models and measured in laboratory experiments, we favor the formation of NH2OH in the interstellar medium via hydrogenation of NO on dust grain surfaces, with possibly a contribution of ice mantle NH3 oxidation processes. Further laboratory studies and quantum chemical calculations are needed to completely rule out the formation of NH2OH in the gas phase.