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Anonymous ID: 83a394 April 16, 2018, 9:05 a.m. No.1065391   🗄️.is đź”—kun   >>5589

pan at a restaurant in San Francisco

On November 30, 2017, the company announced the launch of Just Scramble, a product derived from mung bean that tastes like egg, is free of antibiotics and cholesterol, and its ingredients require less water and emit fewer carbon emissions than conventional eggs.[31] Prior to launch, Just Scramble won "Best Plant-Based Food" at an international protein industry summit[32] and received confirmation of "GRAS" (generally recognized as safe) status from the U.S. Food and Drug Administration.[33] A Business Insider review said "the texture was perfect and the taste was distinctly egg."[34] JUST plans to expand production of Just Scramble in 2018 beginning with foodservice partners in the United States and internationally.[35] In January 2017, JUST formally expanded into Asia with the launch of Just Scramble and several other products at Green Common, which operates healthy casual dining and retail shops in Hong Kong.[36] The company told Quartz that it is looking to get Just Scramble into mainland China, Japan, and India.

 

Cultured (Clean) Meat

JUST is one of a small number of startups working on cultured meat, or clean meat,[37] which is real meat that is created without the need to raise and slaughter animals. The process includes harmlessly extracting cells from an animal and feeding those cells nutrients so they can multiply into a product that can be cooked and eaten. Companies working on cultured meat products say the process is much like brewing beer or making soy sauce, both of which are cultured food products. They also say the end result will be better for the environment, safer for consumers and more humane to animals than conventional meat production. One of the biggest technical challenges is finding cost-effective and scalable nutrients to feed the cells to get them to multiply so that mass quantities of meat can be commercialized and sold. JUST has said it hopes to make its first commercial sale before the end of 2018.

 

“Folks in Silicon Valley think about [lab-made] meat and they think it’s some new thing dreamed up by some teenager in a garage somewhere,” JUST CEO Josh Tetrick told Quartz. But really, it’s been decades in the making. “It wasn’t until recently that the greatness of [Dutch entrepreneur Willem van Eelen’s] idea was met by a society and set of enabling technologies that could make it real,” he said.[38] Ira van Eelen, the elder van Eelen's daughter, serves as an adviser to JUST.[39]

 

Intellectual Property

In September 2017, the U.S. Patent and Trademark Office issued JUST a machine learning patent for food ingredient discovery. U.S. Patent №9,760,834,[40] titled “Discovery Systems for Identifying Entities That Have a Target Property,” covers the company’s machine-learning enabled discovery platform and methods for discovering new plant-based ingredients. The patent relates to a combination of robotics, proprietary plant databases, artificial intelligence and predictive modeling that the company said increases its scientists’ rate of discovery and its ability to bring new products to market.[41]

 

At around the same time, JUST also announced the acquisition of a worldwide patent portfolio covering foundational “clean meat” technology, including clean meat compositions, food products and methods of manufacture. The patents include U.S. Patent №6,835,390 (“Method for Producing Tissue Engineered Meat for Consumption”); U.S. Patent №7,270,829 (“Industrial Production of Meat Using Cell Culture Methods”); and related patents in regions throughout the world including North America, Europe, Asia and the Middle East.

 

https:// en.wikipedia.org/wiki/JUST,Inc.#Cultured(Clean)_Meat

Anonymous ID: 83a394 April 16, 2018, 9:29 a.m. No.1065627   🗄️.is đź”—kun   >>5761

TAR DNA-binding protein 43

https:// en.wikipedia.org/wiki/TARDBP

 

Clinical significance

A hyper-phosphorylated, ubiquitinated and cleaved form of TDP-43—known as pathologic TDP43—is the major disease protein in ubiquitin-positive, tau-, and alpha-synuclein-negative frontotemporal dementia (FTLD-TDP, previously referred to as FTLD-U[13]) and in Amyotrophic lateral sclerosis (ALS).[14] Elevated levels of the TDP-43 protein have also been identified in individuals diagnosed with chronic traumatic encephalopathy, a condition that often mimics ALS and that has been associated with athletes who have experienced multiple concussions and other types of head injury.[15] Abnormalities of TDP-43 also occur in an important subset of Alzheimer's disease patients, correlating with clinical and neuropathologic features indexes.[16]

 

HIV-1, the causative agent of acquired immunodeficiency syndrome (AIDS), contains an RNA genome that produces a chromosomally integrated DNA during the replicative cycle. Activation of HIV-1 gene expression by the transactivator "Tat" is dependent on an RNA regulatory element (TAR) located "downstream" (i.e. to-be transcribed at a later point in time) of the transcription initiation site.

 

Mutations in the TARDBP gene are associated with neurodegenerative disorders including frontotemporal lobar degeneration and amyotrophic lateral sclerosis (ALS).[17] In particular, the TDP-43 mutants M337V and Q331K are being studied for their roles in ALS.[18][19] Cytoplasmic TDP-43 pathology is the dominant histopathological feature of multisystem proteinopathy.[20] The N-terminal domain, which contributes importantly to the aggregation of the C-terminal region, has a novel structure with two negatively charged loops.[21]