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No blood test, but an MRI. MRI will show thinning of the coritcal greiy matter and enlarging of the ventricles in schiz and bipolar.
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Chemical imbalance was just a theory which is being replaced. The replacement is that most psych meds work by reducing inflammation and preventing or reducing oxidative damage. This is all new The famous brain chemicals (norepinephrine/serotonin) have been found to be involved in preventing brain damage as one of their normal functions.