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Anonymous ID: 35ecc0 Nov. 21, 2020, 9:51 a.m. No.11726942   🗄️.is 🔗kun

Family studies have consistently demonstrated that there is a substantial genetic contribution to alcohol dependence. Over the past two decades, several genes underlying susceptibility have been identified. Extensive study of the alcohol metabolizing genes has demonstrated their important role in disease risk. Additional genes have been identified that have expanded our understanding of the genes and pathways involved; however, the number of findings to date is modest. There are several likely reasons for this. First and perhaps foremost, most studies of alcohol-related phenotypes have been small – hundreds or a few thousand samples. Most robust associations that have been reported in common disease have employed tens of thousands of samples and are now beginning to combine several studies of these magnitude into even larger meta analyses. The alcohol research community has begun to form larger consortia for meta-analyses and it is anticipated that with the resulting increase in sample size the number of robust associations will increase. A second approach that will likely benefit the alcohol research community will be greater examination of pathways or gene sets. These approaches have been quite fruitful for some studies and need to be employed in analyses of alcohol-related traits and phenotypes. Over the next few years, we anticipate the identification of additional common and rare variants contributing to the risk of alcohol dependence.

 

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4056340/