Dramatic levels of “friendly fire” from the immune system may drive severe Covid-19 disease and leave patients with “long Covid” – when medical problems persist for a significant time after the virus has been beaten – scientists have said.
Researchers at Yale University found that Covid-19 patients had large numbers of misguided antibodies in their blood that targeted the organs, tissues and the immune system itself, rather than fighting off the invading virus.
The scientists compared immune responses in patients and uninfected people and discovered scores of aberrant antibodies in the former.These blocked antiviral defences, wiped out helpful immune cells, and attacked the body on multiple fronts, from the brain, blood vessels and liver to connective tissue and the gastrointestinal tract.
Further tests revealed that the more “autoantibodies” patients had in their blood, the worse their disease. The Covid-19 patients had more antibodies that had turned on them than people with lupus, an autoimmune disease caused by similar wayward antibodies.
“Covid-19 patients make autoantibodies that actually interfere with immune responses against the virus,” said Aaron Ring, an immunobiologist at Yale and senior author on the study. Numerous other autoantibodies attacked parts of the body that are known to become damaged in those with the disease.
“We certainly believe that these autoantibodies are harmful to patients with Covid-19,” said Ring, adding that the harmful effects may well continue after the infection has abated, leaving patients with longer-lasting medical problems. “Because antibodies can persist for a long time, it’s conceivable that they may contribute to the development of long-Covid diseases,” he said.
Cytokine storm?
Sauce:
https://www.theguardian.com/science/2020/dec/13/autoantibodies-may-be-driving-severe-covid-cases-study-shows