Anonymous ID: f03fda Feb. 16, 2021, 11:55 a.m. No.12947380   🗄️.is 🔗kun   >>7388 >>7439 >>7582

[Part 1]

 

Do you have cancer or know someone who does? The articles and papers below show that the anti-parasite drugs hydroxychloroquine and ivermectin have significant anti-cancer activity. Consider asking your oncologist about this and perhaps requesting a prescription under "off-label" or under "compassionate use" loopholes. Also consider asking a telemedicine doctor from https://speakwithanmd.com/ about getting hydroxychloroquine or ivermectin for preventive (prophylactic) and/or treatment (therapeutic) use for COVID-19. Combatting cancer, COVID, worms, and other parasites - ivermectin is an all-in-one medical tool!

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https://www.cancer.gov/about-cancer/treatment/drugs/off-label

 

Off-Label Drug Use in Cancer Treatment

About Off-Label Drugs

 

Drugs can be legally sold in the U.S. only after the U.S. Food and Drug Administration (also known as the FDA) has approved them. Drugs are approved after research shows they are safe and effective for a specific use.

 

Off-label drug use refers to the practice of prescribing a drug for a different purpose than what the FDA approved. This practice is called “off-label” because the drug is being used in a way not described on its package insert. This insert is known as its “label.”

 

[Much moar at website]

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https://www.cancer.org/treatment/treatments-and-side-effects/clinical-trials/compassionate-drug-use.html

 

Compassionate Drug Use

What is compassionate drug use?

 

Compassionate drug use means making a new, unapproved drug available to treat a seriously ill patient when no other treatments are available.

 

Drugs that are being tested but have not yet been approved by the US Food and Drug Administration (FDA) are called investigational drugs. These drugs are normally available only to people who are taking part in a clinical trial.

 

Being able to use one of these drugs when you are not in a clinical trial is most commonly referred to as compassionate drug use.

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https://jeffreydachmd.com/2016/05/ivermectin-antiparasitic-anticancer-wonder-drug/

 

The 2015 Nobel Prize in Medicine went for discovery of Ivermectin, an “astonishingly safe” FDA approved anti-helminthic drug.

 

200 million people take the drug globally for prevention or treatment of parasitic disease.

 

Dr Sharmeen at the University of Toronto screened a library of 100 drugs for activity against a leukemic cell line, and reported Ivermectin as most promising, inducing leukemic cell death at low micromolar concentrations, while sparing normal cells. Ivermectin was also effective against leukemia mouse xenografts. Ivermectin was patented in 2012 for treating hematological malignancy. Dr Hashimoto reported in 2009, Ivermectin effective against ovarian cancer cell lines (14.)

 

Dr Alice Melotti studied Ivermectin as an inhibitor of the WNT‐TCF pathway in cancer. Her report was published in 2014 EMBO molecular medicine. Dr Melotti used a transcriptional reporter assay for TCF activity driven by Beta-CATENIN to test a collection of 1,040 drugs and small molecules. Only one agent, Ivermectin, perfectly tracked the gene expression profile induced by blocking the TCF gene, and therefore inhibits the WNT pathway. This has profound significance for anti-cancer stem cell therapy, because blocking the WNT pathway is the key to killing cancer stem cells. (15-16) Blocking the WNT pathway in a breast cancer model killed cancer stem cells.(18) Similarly, blocking the WNT pathway in Mantle cell lymphoma preferentially killed the cancer stem cells.(16)

 

[Much moar at website]

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[Go to Part 2]

Anonymous ID: f03fda Feb. 16, 2021, 11:56 a.m. No.12947388   🗄️.is 🔗kun   >>7582

>>12947380

 

[Part 2, Cancer, COVID, Worms, and Ivermectin]

 

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5718030/

 

Repurposing Drugs in Oncology (ReDO)—chloroquine and hydroxychloroquine as anti-cancer agents

Ecancermedicalscience. 2017; 11: 781.

Published online 2017 Nov 23. doi: 10.3332/ecancer.2017.781

 

Abstract

Chloroquine (CQ) and hydroxychloroquine (HCQ) are well-known 4-aminoquinoline antimalarial agents. Scientific evidence also supports the use of CQ and HCQ in the treatment of cancer. Overall, preclinical studies support CQ and HCQ use in anti-cancer therapy, especially in combination with conventional anti-cancer treatments since they are able to sensitise tumour cells to a variety of drugs, potentiating the therapeutic activity. Thus far, clinical results are mostly in favour of the repurposing of CQ. However, over 30 clinical studies are still evaluating the activity of both CQ and HCQ in different cancer types and in combination with various standard treatments. Interestingly, CQ and HCQ exert effects both on cancer cells and on the tumour microenvironment. In addition to inhibition of the autophagic flux, which is the most studied anti-cancer effect of CQ and HCQ, these drugs affect the Toll-like receptor 9, p53 and CXCR4-CXCL12 pathway in cancer cells. In the tumour stroma, CQ was shown to affect the tumour vasculature, cancer-associated fibroblasts and the immune system. The evidence reviewed in this paper indicates that both CQ and HCQ deserve further clinical investigations in several cancer types. Special attention about the drug (CQ versus HCQ), the dose and the schedule of administration should be taken in the design of new trials.

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7505114/

 

Ivermectin, a potential anticancer drug derived from an antiparasitic drug

 

Pharmacol Res. 2021 Jan; 163: 105207.

Published online 2020 Sep 21. doi: 10.1016/j.phrs.2020.105207

 

Abstract

Ivermectin has powerful antitumor effects, including the inhibition of proliferation, metastasis, and angiogenic activity, in a variety of cancer cells. This may be related to the regulation of multiple signaling pathways by ivermectin through PAK1 kinase. On the other hand, ivermectin promotes programmed cancer cell death, including apoptosis, autophagy and pyroptosis. Ivermectin induces apoptosis and autophagy is mutually regulated. Interestingly, ivermectin can also inhibit tumor stem cells and reverse multidrug resistance and exerts the optimal effect when used in combination with other chemotherapy drugs.