Why Crispr and mRNA are dangerous

"I work as a PhD in a gene editing lab using CRISPR technologies to study cancer. It is not needlessly feared. There are some things that we should resolve and be concerned before we use genome editing widely. The number of different types of proteins in body is estimated between 80.000 to 400.000. Basically, we don't even know how many proteins there in the body. We know one function for maybe quarter of those proteins. The remaining 75% has unknown function. Add the fact that each protein can have several different functions and dozens of interactions with different proteins to for more complex structures to accomplish more complex tasks. We don't know in which type of cells, which of those 80 to 400k proteins are activated. We cant even make a good categorization of sub-type of different cells. Thus, we can not even imagine the all consequences of each editing in molecular scale. Yet alone cell scale, tissue scale, organ scale, system scale, organism scale. Because we don't know enough about the rules of the cell yet. For example maybe the transcription factor they edited out is a currently unknown tumor suppressor. And editing that out will result in increased tumorigenesis in these edited cells. And that person will maybe develop cancer due to that editing. We currently don't know for sure, since we dont know enough about the cell yet. That is why genetic engineering has a lot of risks to be assessed before it is used worldwide. By the way there are also several other problems else than that. One last I can mention before it gets too long is the specificity of CRISPR. Yes it is very precise editing compared to older editing tools. Because guide RNA binds to DNA very precisely based on its sequence. Cas9 cuts at the precise location based on guide. However, in real life things doesn't work perfectly. Even if their sequences differ with 1 nucleotide, there is a small chance the guide RNA bind to off target locations with 1 or 2 mismatch. Which means it might binds to off target locations despite not being perfectly complementary to that location. Cas protein can cut at wrong location. Things doesn't work perfectly in cells. But when you apply a therapy to a person, you don't have the luxury of saying of there was a 5% chance of off target cutting and now you have increased chance of cancer. There are rules regulating what you can put into the medical market as a "therapy".