Mission statement for E4B states:
The E-4B serves as the National Airborne Operations Center and is a key component of the National Military Command System for the President, the Secretary of Defense and the Joint Chiefs of Staff. In case of national emergency or destruction of ground command and control centers, the aircraft provides a highly survivable command, control and communications center to direct U.S. forces, execute emergency war orders and coordinate actions by civil authorities. The conduct of E-4B operations encompasses all phases of the threat spectrum. Additionally, the E-4B provides outside the continental United States travel support for the Secretary of Defense and his staff to ensure Title 10 command and control connectivity.
https://www.af.mil/About-Us/Fact-Sheets/Display/Article/104503/e-4b/