https://jvi.asm.org/content/84/7/3134

https://archive.is/2pisp

This work was supported by NIH grants 5F32AI080148 (R.L.G.) and 5R01AI075297 (R.S.B.).

2010

Recombination, Reservoirs, and the Modular Spike: Mechanisms of Coronavirus Cross-Species Transmission

Rachel L. Graham, Ralph S. Baric

DOI: 10.1128/JVI.01394-09

"'Additionally, in our recent reconstruction of the bat SARS-like CoV (Bat-SCoV),we were able not only to replace the RBD of Bat-SCoV with the human equivalent in order to generate infectious progeny but also to generate a recombinant human virus (Bat-F) in which the 5,700 nucleotides (nt), including the S-coding sequence of the RBD, were replaced with those from the Bat-SCoV sequence (10). Both mutants were infectious in primate cells, suggesting an as-yet-undefined plasticity and perhaps a modular design in the Spike protein-coding sequence that allows for robust interchange of component parts.'

That the spike-protein is modular in design and can swap to other viruses. They mention the following viruses that may swap modularity with this human infecting spike-protein:

'This domain organization groups the CoV Spike protein with other class I viral fusion proteins, such as influenza virus hemagglutinin (HA), HIV-1 Env, simian virus 5 (SV5) F, andEbola virus Gp2 (16)(Fig. 2).'

Literally epic doom if you can comprehend the big picture of risk to humanity if normally dangerous but inert viruses become transmissable through this modular recombining process and we have millions and millions of lab-rats producing this spike-protein now."