>>13546281 (lb)
>>13546279 (lb)
Polyethylene glycol (PEG) sensitivity
https://en.wikipedia.org/wiki/Polyethylene_glycol
>PEG is considered biologically inert and safe by the FDA. However, a growing body of evidence shows the existence of a detectable level of anti-PEG antibodies in approximately 72% of the population, never treated with PEGylated drugs, based on plasma samples from 1990–1999.[40][further explanation needed] Due to its ubiquity in a multitude of products and the large percentage of the population with antibodies to PEG, hypersensitive reactions to PEG are an increasing concern.[41][42] Allergy to PEG is usually discovered after a person has been diagnosed with an allergy to an increasing number of seemingly unrelated products, including processed foods, cosmetics, drugs, and other substances that contain PEG or were manufactured with PEG.[41]
https://pubmed.ncbi.nlm.nih.gov/27196817/
>Polyethylene glycols (PEGs) or macrogols are polyether compounds widely used in medical and household products. Although generally considered biologically inert, cases of mild to life-threatening immediate-type PEG hypersensitivity are reported with increasing frequency. Nevertheless, awareness of PEG's allergenic potential remains low, due to a general lack of suspicion towards excipients and insufficient product labelling. Information on immediate-type reactions to PEG is limited to anecdotal reports, and the potential for PEG sensitization and cross-sensitization to PEGylated drugs and structurally related derivatives is likely underestimated. Most healthcare professionals have no knowledge of PEG and thus do not suspect PEG's as culprit agents in hypersensitivity reactions. In consequence, patients are at risk of misdiagnosis and commonly present with a history of repeated, severe reactions to a range of unrelated products in hospital and at home.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6706272/
Immediate Hypersensitivity to Polyethylene Glycols and Polysorbates: More Common Than We Have Recognized
>After encountering two cases of life threatening immediate hypersensitivity to macrogols in our clinic, we sought to further understand the mechanism and scope of immediate hypersensitivity to PEG.
https://pubmed.ncbi.nlm.nih.gov/25730412/
Polyethylene glycols (PEG) and related structures: overlooked allergens in the perioperative setting
>PEGs and PEG analogs are prevalent in the perioperative setting, contained in a wide range of products seldom suspected of causing hypersensitivity reactions and thus rarely documented in surgical/anesthetic records.