https://journals.lww.com/americantherapeutics/fulltext/2021/05000/review_of_the_emerging_evidence_demonstrating_the.4.aspx

After COVID-19 emerged on U.S shores, providers began reviewing the emerging basic science, translational, and clinical data to identify potentially effective treatment options. In addition, a multitude of both novel and repurposed therapeutic agents were used empirically and studied within clinical trials.