https://www.washingtonexaminer.com/news/fauci-denies-nih-supported-gain-of-function-research-wuhan-lab
https://www.phe.gov/s3/dualuse/documents/p3co.pdf
https://www.nature.com/articles/nm.3985
A SARS-like cluster of circulating bat coronaviruses shows potential for human emergence
The emergence of severe acute respiratory syndrome coronavirus (SARS-CoV) and Middle East respiratory syndrome (MERS)-CoV underscores the threat of cross-species transmission events leading to outbreaks in humans. Here we examine the disease potential of a SARS-like virus, SHC014-CoV, which is currently circulating in Chinese horseshoe bat populations1. Using the SARS-CoV reverse genetics system2, we generated and characterized a chimeric virus expressing the spike of bat coronavirus SHC014 in a mouse-adapted SARS-CoV backbone. The results indicate that group 2b viruses encoding the SHC014 spike in a wild-type backbone can efficiently use multiple orthologs of the SARS receptor human angiotensin converting enzyme II (ACE2), replicate efficiently in primary human airway cells and achieve in vitro titers equivalent to epidemic strains of SARS-CoV. Additionally, in vivo experiments demonstrate replication of the chimeric virus in mouse lung with notable pathogenesis. Evaluation of available SARS-based immune-therapeutic and prophylactic modalities revealed poor efficacy; both monoclonal antibody and vaccine approaches failed to neutralize and protect from infection with CoVs using the novel spike protein. On the basis of these findings, we synthetically re-derived an infectious full-length SHC014 recombinant virus and demonstrate robust viral replication both in vitro and in vivo. Our work suggests a potential risk of SARS-CoV re-emergence from viruses currently circulating in bat populations.
>https://www.washingtonexaminer.com/news/fauci-denies-nih-supported-gain-of-function-research-wuhan-lab
Fauci denies NIH supported gain-of-function research at Wuhan lab
Dr. Anthony Fauci denied that the National Institutes of Health had funded gain-of-function research at the Wuhan lab U.S. intelligence is investigating as a possible origin of the COVID-19 pandemic during a testy exchange with Republican Sen. Rand Paul.
Officials from both the Trump and Biden administrations have said that the Chinese government worked for over a year to thwart an independent investigation into the origins of the virus, which has killed 3.3 million people worldwide, according to Johns Hopkins University, and both administrations cast doubt on the manner in which the WHO-China study was conducted in early 2021.
Though the WHO-China report said a jump from animals to humans was most likely, Trump officials have pointed to an accidental escape from the Wuhan Institute of Virology as a highly plausible origin for the pandemic.
On Tuesday, Paul pointed to two broad issues — first, Dr. Ralph Baric at the Gillings School of Global Public Health at UNC-Chapel Hill allegedly “collaborating” with the Wuhan lab’s top scientist, Shi Zhengli, also dubbed the “bat lady,” on experiments related to the original SARS virus years ago. Second, NIH grants going to Peter Daszak’s New York-based EcoHealth Alliance, which then provided some of that funding to the Wuhan lab, which a Trump State Department fact sheet contended carried out secretive gain-of-function experiments.
HHS defines gain-of-function research as research “that improves the ability of a pathogen to cause disease, help define the fundamental nature of human-pathogen interactions, thereby enabling assessment of the pandemic potential of emerging infectious agents” and warns that gain-of-function studies “may entail biosafety and biosecurity risks.”
During a Senate hearing on the coronavirus, Paul first pointed to the work between Baric and Shi as evidence of U.S. support for gain-of-function research in China.
“This gain-of-function research has been funded by the NIH,” Paul contended. “The collaboration between the U.S. and the Wuhan institute continues.” He asked: “Dr. Fauci, do you still support funding of the NIH funding of the lab in Wuhan?”
Fauci, the director of the U.S. National Institute of Allergy and Infectious Diseases and the chief medical adviser to President Joe Biden, replied: “Sen. Paul, with all due respect, you are entirely and completely incorrect — that the NIH has not ever and does not now fund gain-of-function research in the Wuhan Institute of Virology.”
He added: “Dr. Baric is not doing gain-of-function research, and if it is, it is according to the guidelines, and it is being conducted in North Carolina, not in China … If you look at the grant and you look at the progress reports, it's not gain-of-function.”
Zhengli-Li Shi & Ralph S Baric
Zhengli-Li Shi & Ralph S Baric
Zhengli-Li Shi & Ralph S Baric
doesn't exactly roll off the tongue
https://twitter.com/TheInsiderPaper/status/1392245423545389063
https://www.timesofisrael.com/kristallnacht-in-lod-state-of-emergency-as-arab-mobs-set-synagogues-on-fire/
‘Kristallnacht in Lod’: State of emergency as Arab mobs set synagogues on fire
Eruptions of Arab violence across Israel; Lod mayor describes ‘civil war’ in Jewish-Arab city, army sent in as police chief calls situation unprecedented
>Seth Rich Dominion connection
https://twitter.com/AJEnglish
>The video highlights the violent harassment the church is actually receiving from "rainbow community" next door.