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Another Potentially Deadly Tick-Borne Illness May Be A New Problem

May 30, 2021

DAHBOO777

252K subscribers

Gary Wormser, chief of infectious diseases at New York Medical College and director and founder of the Lyme Disease Diagnostic Center, said deer ticks may transmit several diseases, including Lyme, babesiosis and anaplasmosis, which has symptoms and risk factors similar to babesiosis but is generally treated with a different medicine, doxycycline. With Lyme disease and babesiosis, he said, "the ticks have to be on you for a fairly long time before they transmit those particular infections."

Chances of avoiding infection are likely if the tick is removed within 24 to 36 hours. After possible exposure to deer ticks, Wormser advised showering within two hours, running clothes in a hot dryer for at least 10 minutes and doing a total body check for ticks on the skin within 24 hours.-

https://www.yahoo.com/news/another-tick-borne-illness-may-154752074.html

https://youtu.be/-6Wruc40Ow8

>>13795105

>>13795035

I have to translate tthis but here is the link

https://www.franceculture.fr/sciences/le-laboratoire-p4-de-wuhan-une-histoire-francaise

NEWS

Wuhan P4 laboratory: a French story

04/17/2020 (UPDATED AT 12:01 PM)

By Philippe Reltien and Cellule investigation de Radio France

Investigation | Wanted and built with the help of France, the very sensitive P4 virology laboratory in Wuhan, which is now the subject of much speculation, has gradually escaped the control of French scientists. According to our information, a vaccine against Covid-19 was recently tested there.

Inside the Wuhan P4 laboratory in February 2017.

'''Inside the Wuhan P4 laboratory in February 2017. • Credits: Johannes Eisele - AFP

With its 11 million inhabitants, Wuhan is said to be the most French of Chinese cities. There is a museum of French town planning and a TGV station whose roof evokes a migratory bird. Anne-Isabelle Sigros, who was foreman for the AREP architecture firm, remembers: "We were in marshes and fields. We planted the station there, and today the city has it. joined. " On the north shore, there are still traces of the French concession, not far from the now famous indoor fish market of Huanan. On the other side, the rectilinear avenues, which run towards the airport, lead to an industrial zone where a hundred French companies thrive, including Peugeot-Dongfeng, Renault, Eurocopter, Schneider Electric, L'Oréal and Pernod. -Ricard'''

A promising cooperation

In the 2000s, Franco-Chinese cooperation in Wuhan continued in the medical field. In 2003, SARS, severe acute respiratory syndrome hit China. The country needs help. President Jiang Zemin, whose term is ending, is a friend of Dr. Chen Zhu. This Francophile Shanghainese was trained at the Saint-Louis hospital, in the services of a relative of Jacques Chirac, Professor Degos. When Hu Jintao succeeds Jiang Zemin, Jean-Pierre Raffarin goes to meet the doctor. Then, in October 2004, during a trip to Beijing, Jacques Chirac sealed an alliance with his Chinese counterpart.

The two countries decide to join forces to fight emerging infectious diseases. This partnership seems all the more necessary as another virus, the avian flu virus, H5N1, is hitting China.

The idea of P4 takes shape

This gave rise to the idea of building a P4-type laboratory in Wuhan, in collaboration with France. In other words, very high biological safety for the study of unknown pathogenic viruses for which there is no vaccine. There are around thirty of these structures around the world, some of which are labeled by the World Health Organization. But the project provokes resistance. First, French bacteriological warfare experts are reluctant. We are in the aftermath of September 11. The SGDSN (General Secretariat for Defense and National Security) fears that a P4 could turn into a biological arsenal.

Added to this is another grievance on the part of France. China refuses to tell him what happened to the P3 mobile biology laboratories that had been funded by the Raffarin government after the SARS epidemic. "The French were a little cooled by the lack of transparency of the Chinese," explains Antoine Izambard, author of the book Dangerous Liaisons. "Their explanations remained opaque on the use they could make of these P3s. Some in the French administration therefore thought that China would surely make a similar use of the P4. This raised a lot of fears

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These laboratories that fight against the most formidable viruses

The works start

But little by little, these reservations will be lifted. And in 2004, an agreement signed by Michel Barnier, Jacques Chirac's Minister of Foreign Affairs, launched the Chinese P4 project. It remains to find a place. Since Shanghai is too populated, this laboratory will be installed on the outskirts of Wuhan. In 2008, a steering committee was created. It will be directed by a Frenchman, the Lyonnais Alain Mérieux and the doctor Chen Zhu. In 2010, the Sarkozy administration announced to the WHO that the work was starting.

About fifteen very specialized French SMEs then lend their assistance to build the laboratory. "These P4 labs are really top-level technology, comparable to that of French nuclear submarines in terms of the tightness of certain parts", adds Antoine Izambard. But it will be Chinese companies that will provide most of the construction, which is not always to the taste of the French. Technip, for example, will refuse to certify the building.

On January 31, 2015, the work finally ended. In his book, Antoine Izambard describes an austere place. "At the end of a 6-lane road" he writes, there is "a huge red brick building under construction (intended to accommodate 250 researchers in residence), another high

this is the French Institute that built the WUHAN lab.Institut Merieux

https://www.institut-merieux.com/en/home/

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>>13795242

another highly secure that one would take for a prison (a 4-storey bunker with 4 watertight labs), and a last white and rectangular on which is written "Wuhan Institute of Virology".

Wuhan P4 laboratory on April 17, 2020.

Wuhan P4 laboratory on April 17, 2020. • Credits: Hector Retamal - AFP

The Chinese are taking back control

In 2015, Alain Mérieux left the co-chairmanship of the Joint Commission which oversaw the project. At the time, he told the microphone of Radio France in Beijing: "I am giving up the co-presidency of P4 which is a very Chinese tool. It belongs to them, even if it was developed with technical assistance from France. " But that doesn't mean cutting all ties. “Between the P4 in Lyon and the P4 in Wuhan,” he explains, “we want to establish close cooperation. In China, there are a lot of animals, poultry farming, pig problems, which themselves are virus carriers. It is unthinkable that China does not have a high-security laboratory to isolate novel germs, many of which are of unknown etiology. "

A trompe l'oeil collaboration

On February 23, 2017, the former Prime Minister Bernard Cazeneuve and the Minister of Health Marisol Touraine announced that 50 French researchers will come in residence at P4 in Wuhan for five years. France then undertakes to provide it with technical expertise, as well as training to improve the level of biosafety in the laboratory, and to launch a joint research program. But the French researchers will never come. For Marisol Touraine, "It's a shame insofar as we launched the project with the hope that it would bring shared knowledge. We obviously could not anticipate the current epidemic. But in February 2017, we were betting on the hopes of this cooperation. "

Regardless, the lab will be put into operation in January 2018. It coincides with Emmanuel Macron's first state visit to Beijing.

But from the start doubts set in as to its reliability. According to the Washington Post, in January 2018, members of the US Embassy visited the premises and alerted Washington to inadequate security measures taken at a location studying coronaviruses from bats.

Another disappointment: the hoped-for Franco-Chinese cooperation between the P4 Jean Mérieux-Inserm of Lyon Bron and that of Wuhan will never really start. Alain Mérieux himself confirms it to the investigation unit of Radio France: "We can say without revealing a state secret that since 2016 there has been no meeting of the Franco-Chinese Committee on Infectious Diseases", recognizes -he. Contrary to initial promises, the Chinese therefore work without any outside view from French researchers. "The laboratory is far from running at full speed", adds Antoine Izambard. "They have built a huge building that is to accommodate 250 researchers, but they are not there yet. Normally, there are only a few Chinese researchers from the Wuhan Institute of Virology who conduct research on animals in link with three diseases, Ebola, Congo Crimean hemorrhagic fever, and NIPAH "(a virus carried by pigs and bats).

Another missed opportunity

Before the Covid 19 crisis, another collaboration seemed to want to take shape. In 2019, Chinese President Xi Jinping asked one of the vice-chairmen of the People's Congress standing committee to imagine what a health shield could be for Yunnan province. There, many men rub shoulders with wild animals. This promiscuity creates a risk of the appearance of new viruses transmissible to humans. "It is a large country which has quite upset its ecosystems with gigantic crops and livestock" confirms Gilles Salvat, veterinary doctor and director general of research at ANSES. "It is true that it is a source of virus because of the interactions of wild and domestic animals on a country, continent with all climates."

Creating a surveillance center in the greater region could therefore make it possible to prevent the development of new viruses, such as coronaviruses for example. Once again, it is Doctor Chen Zhu who is leading this project. He talks about it to his friend Alain Mérieux. The latter discusses it with Philippe Etienne, who was then diplomatic adviser to President Macron. According to a Chinese online media, China-info.com, a project is taking shape. It consists of creating a sentinel network that would bring together the Instituts Pasteur France, with branches of the Mérieux Foundation in Laos, Cambodia, and Bangladesh. But once again, the enthusiasm will be short-lived. On March 24, Xi Xinping, Emmanuel Macron and their wives dine at Villa Kérylos, on the French Riviera. The next day, the final communiqué made no mention of this project. It will also not be mentioned during Emmanuel Macron's official trip to China in

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>>13795261

According to a Chinese online media, China-info.com, a project is taking shape. It consists of creating a sentinel network that would bring together the Instituts Pasteur France, with branches of the Mérieux Foundation in Laos, Cambodia, and Bangladesh. But once again, the enthusiasm will be short-lived. On March 24, Xi Xinping, Emmanuel Macron and their wives dine at Villa Kérylos, on the French Riviera. The next day, the final communiqué made no mention of this project. Nor will it be mentioned during Emmanuel Macron's official trip to China in November 2019. It is true that another sensitive subject is attracting attention. Swine fever has arrived in France, and farmers are pushing to be able to continue exporting to China. The health shield will therefore be put aside until later …

A vaccine trial in humans

Wuhan's P4, however, will not have remained inactive during the outbreak of Covid-19. It was here that, according to two reliable sources, although not confirmed by Chinese authorities, in late December 2019, Professor Shi Zhengli identified the novel coronavirus from samples taken from five patients in Wuhan municipal hospitals. On January 3, the complete sequencing of its genome begins in another laboratory, the P3 of the Shanghai Central Public Health Clinic, which will then share it with other countries. At the same time, Wuhan's P4 is working on an infected guinea pig monkey, with the aim of obtaining a serum. "The Chinese are good candidates for producing a vaccine," said Gilles Salvat. "They have students all over the world. They have 40 researchers on one subject when we have two. Their firepower is formidable when it comes to innovation and biology."

Officially, the P4 closes on January 23, when confinement is pronounced in Wuhan. But according to several French and Chinese sources contacted by the investigation unit of Radio France, in mid-March, a vaccine trial took place in partnership with a Chinese biotechnology company. According to our information, a virus was first inoculated in monkeys, before being inactivated and then injected into volunteer staff from the institute on which the laboratory depends. "The first inoculated are volunteers and it went well" confirmed to us Doctor Zhao Yan, who co-manages the Zhongnan Hospital in Wuhan: "There are doctors who participate. I know that there was a first. series of a small number, and a second series of tests is in progress on a relatively large number ". According to Frédéric Tangy of the Pasteur Institute, however, for this type of inactivated virus vaccine, "There is a risk of exacerbation of the disease. It is a disaster. It is the worst thing to do."

The P4 in the global race

The P4 is therefore in a vaccine race, as are other countries. On March 16, the American company Moderna in Cambridge, headed by Frenchman Stéphane Bancel, also announced that it had started a clinical trial in Seattle on 45 healthy patients. Sanofi is also working with an American military team. As for the Pasteur Institute, in July it is due to start a clinical trial on volunteers with a vaccine derived from that of measles. But here again, caution must remain in order, since three phases of conclusive trials are needed, with a significant percentage of cures in more than 60 to 70% of patients of different origin and ages, before approving a vaccine.