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In the near future, the powerful Umbrella Corporation has a hidden research facility called The Hive underneath Raccoon City, where the scientists develop genetically engineered drugs for medical purpose and biological weapons. After stealing the lethal T-virus, a thief contaminates The Hive and the artificial intelligence Red Queen seals the Hive and kills all the staff and guinea pigs. A woman called Alice awakes naked in a bathroom of a mansion without memory and soon a commando led by a man called One subdues her and another man called Matt, who claims to be a cop. Alice learns that she is a security guard with her partner Spence assigned to protect the entrance to The Hive and her memory will return in an undefined period since she was affected by a gas. The Red Queen had a malfunctioning five hours ago and had shut down the facility and killed everybody releasing a lethal gas. Now they need to shut down the Red Queen and restart her systems. They use an underground train to reach The Hive and the Red Queen asks then to leave the place. However Kaplan disables the Red Queen opening the doors in The Hive. Soon the group learns that the staff has turned into zombies and now they are under siege of the zombies. Most of the commando dies and only Alice, Spence, Matt, Rain and Kaplan survive. Now they need to find a way to escape from The Hive since the system will shut down the exits in a short period. Who will survive?