Several times Q has said:

Now comes the pain. What could it mean? Is it an anagram?

Well, it likely has more than one meaning. One is exactly what it says but if we look at anagrams we get

compensation Howe

Is someone named Howe involved who might finally get compensated?

Th. Paine COS women

This is more like it. Thomas Paine was in favor of the rights of women. There is a publication called True Pundit written by someone using Paine's name as a pseudonym. So will there be a revelation about some women doing COSplay? Isn't that the WITCHES that we have been hunting in our WITCH HUNT.

Hillary and her coven and the affiliated covens around the world.

Here are two women in COS play in 2014. Sending a message by their weird costumes.