PEGylated nano-graphene oxide as a nanocarrier for delivering mixed anticancer drugs to improve anticancer activity
https://web.archive.org/web/20210706024133/https://www.nature.com/articles/s41598-020-59624-w
Due to their high specific surface area, graphene oxide and graphene oxide-base nanoparticles have great potential both in dual-drug delivery and combination chemotherapy.
https://web.archive.org/web/20210706032353/https://www.sciencedirect.com/science/article/abs/pii/S1742706120303305?via%3Dihub
Thrombus inducing property of atomically thin graphene oxide sheets
Here we report for the first time that atomically thin GO sheets elicited strong aggregatory response in platelets through activation of Src kinases and release of calcium from intracellular stores. Compounding this, intravenous administration of GO was found to induce extensive pulmonary thromboembolism in mice. Prothrombotic character of GO was dependent on surface charge distribution as reduced GO (RGO) was significantly less effective in aggregating platelets. Our findings raise a concern on putative biomedical applications of GO in the form of diagnostic and therapeutic tools where its prothrombotic property should be carefully investigated.
https://web.archive.org/web/20210706034440/https://pubmed.ncbi.nlm.nih.gov/21574593/
Effects of Graphene Oxide Nanoparticles on the Immune System Biomarkers Produced by RAW 264.7 and Human Whole Blood Cell Cultures.
Graphene oxide nanoparticles (GONPs) have attracted a lot of attention due to their many applications… The current study shows that GONPs modulate immune system biomarkers and that these may pose a health risk to individuals exposed to this type of nanoparticle.
https://web.archive.org/web/20210706035342/https://europepmc.org/article/PMC/5853756