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UK Researchers: Cholesterol Drug Reduces Covid-19 Infection by 70%
A drug that treats cholesterol reduces Covid infection by 70% in lab studies, according to a team of researchers in the UK.
The researchers published their findings in the Frontiers in Pharmacology journal on Friday.
Fenofibrate and fenofibric acid significantly reduced Covid infection in human cells so expect this affordable medication to be blacklisted soon.
“Our data indicates that fenofibrate may have the potential to reduce the severity of COVID-19 symptoms and also virus spread,” Dr. Elisa Vicenzi of the San Raffaele Scientific Institute in Milan and co-author, said in the release. “Given that fenofibrate is an oral drug which is very cheap and available worldwide, together with its extensive history of clinical use and its good safety profile, our data has global implications.”
Fox News reported:
A drug meant to treat cholesterol was found to reduce coronavirus infection by 70% in lab studies, with researchers calling for additional clinical trials among hospitalized COVID-19 patients.
The team called for added clinical trials to explore use of the drug as a potential COVID-19 therapy, while noting studies are ongoing at the University of Pennsylvania and Hebrew University of Jerusalem. Dr. Farhat Khanim of the University of Birmingham and corresponding study author, cited viral variants spurring rising infection rates and deaths in countries around the world.
“Whilst vaccine programmes will hopefully reduce infection rates and virus spread in the longer term, there is still an urgent need to expand our arsenal of drugs to treat SARS-CoV-2-positive patients,” Khanim wrote.
Another author noted that significant proportions of populations in most low-and-middle countries will likely go unvaccinated until 2022.
“Whilst vaccination has been shown to reduce infection rates and severity of disease, we are as yet unsure of the strength and duration of the response. Therapies are still urgently needed to manage COVID-19 patients who develop symptoms or require hospitalisation,” Dr Alan Richardson, of Keele University in the UK, wrote in part.
The drug was suggested to work by inhibiting the harmful overproduction of cytokines tied to coronavirus infection, and also treat airway inflammation. Additional properties could prevent blood clotting seen in late-stage disease in many COVID-19 patients, study authors noted.
https://www.thegatewaypundit.com/2021/08/uk-researchers-cholesterol-drug-reduces-covid-19-infection-70/
The Hyperlipidaemic Drug Fenofibrate Significantly Reduces Infection by SARS-CoV-2 in Cell Culture Models
The severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) pandemic has caused a significant number of fatalities and worldwide disruption. To identify drugs to repurpose to treat SARS-CoV-2 infections, we established a screen to measure the dimerization of angiotensin-converting enzyme 2 (ACE2), the primary receptor for the virus. This screen identified fenofibric acid, the active metabolite of fenofibrate. Fenofibric acid also destabilized the receptor-binding domain (RBD) of the viral spike protein and inhibited RBD binding to ACE2 in enzyme-linked immunosorbent assay (ELISA) and whole cell-binding assays. Fenofibrate and fenofibric acid were tested by two independent laboratories measuring infection of cultured Vero cells using two different SARS-CoV-2 isolates. In both settings at drug concentrations, which are clinically achievable, fenofibrate and fenofibric acid reduced viral infection by up to 70%. Together with its extensive history of clinical use and its relatively good safety profile, this study identifies fenofibrate as a potential therapeutic agent requiring an urgent clinical evaluation to treat SARS-CoV-2 infection.
https://www.frontiersin.org/articles/10.3389/fphar.2021.660490/full