PTPN22 for global population reduction via

"==PTPN22 contributes to exhaustion of T lymphocytes

during chronic viral infection=="

Christian J. Mainea, John R. Teijaroa, Kristi Marquardta, and Linda A. Shermana

Department of Immunology and Microbial Sciences, The Scripps Research Institute, La Jolla, CA 92037

Edited by Rafi Ahmed, Emory University, Atlanta, GA, and approved October 5, 2016 (received for review March 6, 2016)

https://www.pnas.org/content/pnas/113/46/E7231.full.pdf

The protein encoded by the autoimmune-associated protein tyrosine

phosphatase nonreceptor type 22 gene, PTPN22, has wide-ranging

effects in immune cells including suppression of T-cell receptor signaling and promoting efficient production of type I interferons (IFN-I)

by myeloid cells. Here we show that mice deficient in PTPN22 resist

chronic viral infection with lymphocytic choriomeningitis virus clone

13 (LCMV cl13). The numbers and function of viral-specific CD4

T lymphocytes is greatly enhanced, whereas expression of the

IFNβ-induced IL-2 repressor, cAMP-responsive element modulator

(CREM) is reduced. Reduction of CREM expression in wild-type CD4

T lymphocytes prevents the loss of IL-2 production by CD4 T lymphocytes during infection with LCMV cl13. These findings implicate the

IFNβ/CREM/IL-2 axis in regulating T-lymphocyte function during

chronic viral infection.

Significance

Some viruses, including lymphocytic choriomeningitis virus clone

13, shut down the ability of CD4 T lymphocytes to produce IL-2, a

cytokine required for the survival and function of T lymphocytes.

This shutdown contributes to exhaustion of CD4 and CD8 T lymphocytes and chronic viral infection of the host. The underlying

mechanism responsible for the loss of cytokine production by CD4

T cells remains poorly understood. We demonstrate that the expression of a protein tyrosine phosphatase, PTPN22, contributes to

chronic viral infection. PTPN22 increases the production of IFN-β

following infection, resulting in increased expression of the cAMP

response element modulator (CREM) in CD4 T lymphocytes. CREM

prevents production of IL-2, thereby contributing to T-cell exhaustion and chronic viral infection

>>14290492

https://www.scripps.edu/newsandviews/e_20161107/sherman.html

Scientists Identify Protein Behind Immune System 'Shut Down'PTPN22

By Madeline McCurry-Schmidt

In a new study with broad implications for treating cancers and chronic viral infections, scientists at The Scripps Research Institute (TSRI) have uncovered a mechanism behind a phenomenon called “T cell exhaustion.” T cell exhaustion occurs when the body damps down the immune system once it realizes a virus or tumor has the upper hand—in HIV infections, for example.

The scientists’ research points to a specific protein that works to cripple the immune system’s T cells in these cases, hampering the body’s ability to respond over the long-term to chronic conditions.

“This might have important implications for HIV and tumor immunity,” said TSRI Professor Linda Sherman, who was senior author of the new study.

The study, published the week of October 31, 2016 in the journal Proceedings of the National Academy of Sciences, focused on a protein called PTPN22.

Harnessing T Cells

Sherman and her colleagues knew that PTPN22 was expressed in all immune cells, and that individuals that expressed an altered form of the PTPN22 protein had significantly increased risk for type 1 diabetes and many other autoimmune diseases—signs of an overactive immune system.

“T lymphocytes are very destructive, so if the virus is there to stay, the body wants the immune system to shut off to stop doing damage to the organism,” said Sherman.

This led the researchers to wonder: Could deficiency of this protein work in reverse to prevent the immune system from establishing T cell exhaustion?

Sherman and her colleagues tested this hypothesis by infecting mouse models with a clone of lymphocytic choriomeningitis virus (LCMV), which causes chronic infections similar to HIV and hepatitis.

The researchers found that mice without PTPN22 were able to clear LCMV infections, while mice with PTPN22 showed chronic infection and signs of T cell exhaustion.

“The animals deficient in the PTPN22 protein shrugged off the virus very quickly, rather than having the immune system shut down the way it normally does when it encounters this virus,” said Sherman.

Next, the researchers took a closer look at the mechanisms that made this defense possible. They found that PTPN22 in certain immune cells increases the production of an immune system molecule called interferon beta, which in turn increases the production of a protein called CREM. This leads to the depletion of interleukin 2, an anti-inflammatory molecule crucial to T cell function.

Removing PTPN22 from this system keeps T cells functioning. This explains why animal models with the inactive allele of the PTPN22 gene can better fight LCMV.

This finding could also provide an evolutionary reason why so many people—about 10 percent of the U.S. and European populations—have the inactive PTPN22 allele. While they have increased risk for autoimmune disease, the tradeoff may be a better ability to fight off chronic infections.

“There’s still so much to learn about the immune system,” said Sherman.

The team’s next step will be to study PTPN22’s role in more kinds of cells. “We have to understand what’s going on so we can take advantage of that to make new types of drugs,” Sherman said.

In addition to Sherman, authors of the study, “PTPN22 contributes to exhaustion of T cell lymphocytes during chronic viral infection,” included Christian J. Maine, John R. Teijaro and Kristi Marquardt, all of TSRI at the time of the study.

The study was supported by the National Institutes of Health (grants AI119353 and 1R01AI123210)

https://www.scripps.edu/newsandviews/e_20161107/sherman.html

https://archive.is/maP2e

notable

>>14290492

>>14290504

"PTPN22 encodes a lymphoid-specific tyrosine phosphatase (LYP) that is amaster regulator of the immune response/ This gene is a major susceptibility factor for a wide range of autoimmune conditions… "

The potential of PTPN22 as a therapeutic target for rheumatoid arthritis

https://pubmed.ncbi.nlm.nih.gov/30251905/

"PTPN22 encodes a phosphatase that regulates the phosphorylation status of several kinases important to T cell activation, including Lck and ZAP70".

From: Kelley and Firestein's Textbook of Rheumatology (Tenth Edition), 2017

https://www.sciencedirect.com/topics/biochemistry-genetics-and-molecular-biology/ptpn22

PTPN22: its role in SLE and autoimmunity

Sharon A Chung 1, Lindsey A Criswell

Affiliations expand

PMID: 18075792 PMCID: PMC2875134 DOI: 10.1080/08916930701510848

Free PMC article

Abstract

A functional variant of protein tyrosine phosphatase nonreceptor 22 (PTPN22) has recently been shown to be associated with multiple autoimmune diseases, including systemic lupus erythematosus (SLE), rheumatoid arthritis, type 1 diabetes, and autoimmune thyroid disease. In this review, we discuss the structure and function of this gene and its disease-associated polymorphisms. In addition, we review the studies investigating the association between this gene and SLE, along with other autoimmune diseases.

https://pubmed.ncbi.nlm.nih.gov/18075792/

>>14290504

>>14290492

>>14290520

PTPN22 gene

protein tyrosine phosphatase, non-receptor type 22

The PTPN22 gene provides instructions for making a protein that belongs to the PTP (protein tyrosine phosphatases) family. PTP proteins play a role in regulating a process called signal transduction. In signal transduction, the protein relays signals from outside the cell to the cell nucleus. These signals instruct the cell to grow and divide or to mature and take on specialized functions.

The PTPN22 protein is involved in signaling that helps control the activity of immune system cells called T cells.T cellsidentify foreign substances and defend the body against infection.

https://medlineplus.gov/genetics/gene/ptpn22/

>>14290541

>>14290504

>>14290492

>>14290520

PTPN22 protein tyrosine phosphatase non-receptor type 22 [ Homo sapiens (human) ]

Gene ID: 26191,updated on 19-Jul-2021

Download Datasets

https://www.ncbi.nlm.nih.gov/gene/26191

https://en.wikipedia.org/wiki/PTPN22

"Disease association

The common 1858T (rs2476601) Arg620Trp nonsynonymous single nucleotide polymorphism located in the PTPN22 gene has been associated with autoimmune disorders, including an increased risk of Type 1 Diabetes, rheumatoid arthritis, lupus, Vitiligo and Graves' disease, but a decreased risk of Crohn's disease." "Mutations in PTPN22 are over-represented in breast cancer."

Official Symbol

PTPN22provided by HGNC

Official Full Name

protein tyrosine phosphatase non-receptor type 22provided by HGNC

Primary source

HGNC:HGNC:9652

See related

Ensembl:ENSG00000134242 MIM:600716

Gene type

protein coding

RefSeq status

REVIEWED

Organism

Homo sapiens

Lineage

Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo

Also known as

LYP; PEP; LYP1; LYP2; PTPN8; PTPN22.5; PTPN22.6

Summary

This gene encodes of member of the non-receptor class 4 subfamily of the protein-tyrosine phosphatase family. The encoded protein is a lymphoid-specific intracellular phosphatase that associates with the molecular adapter protein CBL and may be involved in regulating CBL function in the T-cell receptor signaling pathway. Mutations in this gene may be associated with a range of autoimmune disorders including Type 1 Diabetes, rheumatoid arthritis, systemic lupus erythematosus and Graves' disease. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Mar 2009]

Expression

Biased expression in bone marrow (RPKM 9.6), lymph node (RPKM 7.9) and 13 other tissues

>>14290157

> "SHEPHARD KING"

goat worship = lamb sacrifice

two side same coin

>>14290186

to keep the gates gmo mosquitoes contained within the party only or nah?

>>14290188

>>14290220

sweden big CF donors…

https://www.clintonfoundation.org/contributors?category=%2410%2C000%2C001+to+%2425%2C000%2C000

>>14290443

not watches, tablets, laptops, and towers too?

just apple?

not carriers doing this too?

not LEO local/federal?

bullshit. all tech is a MitM

>>14290514

you are aware of weather maiipulation capabilities. ask someone with a satellite too in case 'god' says no.

declassed over 10 years ago

https://www.foxnews.com/tech/army-looks-to-strike-foes-with-lightning-weapon

>>14290603

ty

>>14290608

Este

Estee Lauder

Ronald Lauder

World Jeswish Congress

https://en.wikipedia.org/wiki/Ronald_Lauder

Ronald Steven Lauder (born February 26, 1944) is an American businessman, billionaire, philanthropist, art collector, and political activist. He is currently the President of the World Jewish Congress.[2] He and his brother, Leonard Lauder, are the sole heirs to the Estée Lauder cosmetics company, founded by their parents, Estée Lauder and Joseph Lauder, in 1946.

>>14290799

see "MEGA group"

https://larouchepub.com/other/2001/2833mega_spy.html

August 31, 2001 issue of Executive Intelligence Review.

Israeli Spies: =='Mega Was Not

an Agent; Mega Was the Boss'==

by Jeffrey Steinberg

For a brief period of time in early 1997, the Central Intelligence Agency, the Federal Bureau of Investigation, and the National Security Agency engaged in a frantic mole hunt for an Israeli spy, believed to be operating inside the highest levels of the Clinton Administration national security establishment. By the time the mole hunt was made publicin a May 7, 1997 Washington Post leakthe hunt had been abruptly ended, and for all intents and purposes, the story disappeared from the news within a matter of days.

According to the Post account, in January 1997, the National Security Agency (NSA) had intercepted a phone conversation between an Israeli official at the embassy in Washington, and Danny Yatom, the head of the Mossad, Israel's foreign intelligence service. The official sought permission from the spy boss to "go to Mega" in order to obtain a copy of a confidential letter that had been sent by then-U.S. Secretary of State Warren Christopher to Palestinian Authority President Yasser Arafat, concerning U.S. assurances about a recently negotiated agreement for an Israeli military withdrawal from the Hebron area in the West Bank. Yatom, according to the NSA intercept, rejected the request, admonishing his agent, "This is not something we use Mega for."

The idea that the Israeli government was running another spy operation inside the U.S. national security establishment created a tremendous stir. The Washington Post, in its May 7, 1997 leak, had reported, "One official with knowledge of the FBI investigation into the identity of Mega cautioned that much remained unknown. But the official said that if it turned out that a senior U.S. official was passing sensitive information to Israeli authorities, it could prove more serious than the espionage case involving Jonathan Jay Pollard, a former Navy analyst who was convicted in 1986 of selling U.S. military intelligence documents to Israel."

To this day, the Pollard affair is a hot-button issue inside the U.S. intelligence community. At the time of Pollard's arrest in November 1985, it was known that the Navy analyst had been "tasked" to obtain specific U.S. military intelligence secrets, by someone much higher up in the U.S. intelligence community. To this day, the hunt for "Mr. X," Pollard's inside controller, continues. In 1986, EIR had revealed the existence of not merely a "Mr. X," but an "X Committee," made up of nearly a dozen top-level Pentagon and National Security Council officials, all suspected of having been part of the Pollard spy network.

part 1

>>14290813

MEGA group

part 2

Given the seriousness of the Mega security breach, the abrupt shutdown of the mole hunt naturally prompted some wild speculation about the circumstances under which the search for Mega was abandoned. In March 1999, British author Gordon Thomas released a book, Gideon's Spies, which alleged that Israel had blackmailed the Clinton Administration, with the threat to release tapped telephone conversations between the President and Monica Lewinsky, to force Washington to abandon the Mega hunt. Indeed, in her testimony before independent counsel Kenneth Starr, Lewinsky had reported that the President had warned her, on March 29, 1997, at the height of the Mega hunt, that he suspected the White House telephones were being tapped by agents of an unnamed foreign country.

Years later, it was revealed that the White House communications system had been overhauled and modernized during the early Clinton era, and one of the main outside contractors involved in the project was an Israeli firm, Amdocs. According to a May 2000 story in Insight magazine, Amdocs employees would have had nearly unfettered access to White House telephone lines and other super-sensitive communications equipment. However, the nature of the request from the Mossad man in Washington to Yatom—to obtain a confidential State Department document—rules out the possibility that Mega was an electronic eavesdropping source.

Mega-Suspects

Even though the Mega hunt was formally called off, still in some U.S. intelligence quarters, the effort to unearth the suspected Israeli spy cell apparently continued. In September 2000, a CIA team of counterintelligence specialists arrived in Israel, after U.S. Ambassador Martin Indyk had his security clearances temporarily lifted. Ostensibly, Indyk had breached security guidelines by bringing classified U.S. government documents to his residence in Tel Aviv. But it later was revealed that the CIA probe was triggered by an August 2000 unauthorized meeting between Indyk and the former head of the Mossad, Ephraim Halevy, which the ambassador had never reported back to Washington.

If there were anyone in the Clinton Administration's political hierarchy who was a prime candidate to be the Israeli spy Mega, it was Indyk. A British-born Australian citizen, Indyk had been Australia's top Mideast security official in the late 1970s, as deputy director of current Mideast intelligence at the Australian Office of National Assessments, the equivalent of the U.S. National Security Council. But, Indyk abruptly quit the post after just ten months, prompting speculation that he had come under suspicion of spying for Israel (he had lived in Israel while completing his dissertation on "The Power of the Weak: The Ability of Israel and Egypt to Resist the Policies of their Super-Power Patrons"). According to British journalist Kevin Dowling, Indyk next surfaced in Israel, as a "media consultant" to Israel's Likud Prime Ministers, Menachem Begin and Yitzhak Shamir.

In 1982, Indyk came to America, ostensibly on a six-month sabbatical from his duties with the Office of the Israeli Prime Minister. Based out of Cornell University, Indyk formed a research department for the America-Israeli Public Affairs Committee (AIPAC), the "official" Israeli lobby in the United States. Within a year, AIPAC had ponied up $100,000 to Indyk to hive off the research unit as the Washington Institute for Near East Policy (WINEP). Pro-Israel luminaries in Washington, including former Vice President Walter Mondale, former Secretaries of State George Shultz and Alexander Haig, and former United Nations Ambassador Jeane Kirkpatrick, were among the initiating members of WINEP's advisory board, according to Dowling's Sept. 27, 2000 account of the Indyk counterintelligence probe.

>>14290815

Mega group

part 3

Indyk's "six-month sabbatical" never ended, but it was not until 1987 that the Australian got his first green card, permitting him to work in the United States. Indyk was made a U.S. citizen on Jan. 12, 1993—just eight days before he was appointed to the incoming Clinton Administration's National Security Council (NSC) staff as Senior Director for Near East and South Asian Affairs. Indyk had already been an informal Mideast policy adviser to President George H.W. Bush, at the initiative of Dennis Ross, Bush's Assistant Secretary of State, previously a deputy to Indyk at WINEP. At the time of the Mega hunt, Indyk had Ross' old job as Assistant Secretary of State for the Near East.

Another prime suspect in the Mega mole hunt was Leon Fuerth, Vice President Albert Gore's national security adviser, and another well-known pro-Likud fanatic. The Washington Post, in a 1998 profile of Fuerth, reported that he was suspected by U.S. intelligence officials of passing sensitive U.S. policy information to Israeli Prime Minister Benjamin Netanyahu (Likud), a passionate, personal enemy of President Clinton, who was suspected of activating the Mega spy operation.

Also on the Mega list of suspects inside the Clinton national security apparatus was Richard Clarke, the National Security Council "counterterrorism czar," who was fired from the State Department and brought onto the Bush Administration NSC in 1992, after he was accused by the State Department's Inspector General of concealing illegal Israeli arms sales to China.

The Purloined Letter Principle

While all of the above-mentioned Bush- and Clinton-era national security operatives may have been, indeed, secretly, or not-so-secretly passing critical American policy papers and classified documents to the Likud faction in Israel; and, while then-Israeli Prime Minister Netanyahu and his Mossad mandarins may have been attempting to blackmail the President, there is a much simpler answer to the Mega puzzle: Mega was not a deep mole inside the White House. Mega was a far more visible, far more powerful entity, known among its several dozen members as "the Mega Group."

The existence of the Mega Group came to light, almost exactly a year after the Washington Post revealed that the mole hunt was under way. Yet, the story of the Mega Group, which appeared in the Wall Street Journal on May 4, 1998, made no mention of espionage, and did not mention the Mossad, the CIA, or Monica Lewinsky, even in passing. Despite that, the Mega Group precisely fits the story of the illusive mole hunt, in a manner that has profound policy implications to this day, as President George W. Bush struggles to avoid an outbreak of war in the Middle East, which would have devastating consequences for the entire planet.

Under the innocent headline, "Titans of Industry Join Forces To Work for Jewish Philanthropy," Wall Street Journal staff reporter Lisa Miller reported on an April 1998 gathering of some 20 Jewish billionaires, at the Manhattan apartment of hedge-fund manager Michael Steinhardt. That gathering involved some of the most powerful names in the Jewish lobby in America, starting with Edgar Bronfman, the chairman of the World Jewish Congress. Others included: Charles Bronfman, Edgar's brother and a top executive of the family's flagship Seagrams Corp.; Leslie Wexler of Limited, Inc.; Charles Schusterman, chairman of Samson Investment Co. of Tulsa, Oklahoma; Harvey "Bud" Meyerhoff, a fabulously wealthy and powerful Baltimore real estate magnate; Laurence Tisch, chairman of Loews Corp.; Max Fisher, the Detroit oil magnate and Republican Party powerhouse; bagel magnate Max Lender; and Leonard Abramson, the founder of U.S. Healthcare.

>>14290819

Mega group part 4

Introducting the 'EMET PROJECT'

According to the Journal account, the Mega Group was founded in 1991 by Wexler and Charles Bronfman, to add greater clout to the Israeli lobby, by establishing an informal, but all-powerful policymaking group, able to deploy billions of dollars in "charitable" funds for the maximum effect on U.S. policy toward Israel, the Mideast, and other issues of paramount importance to the Jewish megabillionaires. The Mega Group convenes twice a year, for two-day sessions, where, behind closed doors, the members make life-and-death decisions, affecting U.S. policy. Membership is by invitation only; the meetings are secret (the Wall Street Journal story was the only coverage to ever appear in the U.S. media about the existence of the Mega Group, before the publication of this EIR account); and the members each kick in $30,000 in annual dues, to cover "operating expenses" for the twice-yearly sessions.

Charles Bronfman reflected the Mega Group's propensity for secrecy, when he told the Journal's Lisa Miller, "From the beginning we didn't want to be seen as a threat to anybody. And that still pertains. We don't want to be seen as the Sanhedrin," a reference to the highest court of the ancient Jews. "We don't want to be looked at crooked." Charles' far more sinister and slick brother, Edgar, tried to dismiss the activities of the Mega Group, telling Miller, "We want to make it cool to be Jewish."

Not So Cool

But then, a March 13, 2001 dispatch by the Jewish Telegraph Agency revealed that the Mega Group is more than a loose bunch of Jewish billionaires out to do good. The JTA reported that newly installed Israeli Prime Minister Ariel Sharon was about to launch a two-pronged propaganda offensive inside the United States, aimed at winning American support for his plans to overturn the Mideast peace process. First, the JTA revealed, the Sharon government announced that it was hiring two U.S. public relations firms—Rubenstein Associates and Morris, Carrick and Guma—to peddle the Israeli government "spin" inside the U.S. media and in policymaking circles in New York and Washington.

The JTA wire continued, "More controversially, a handful of Jewish mega-donors has created a think-tank they hope will generate long-term strategies for presenting Israel in a favorable light."

The new think-tank, Emet (the Hebrew word for "truth"), JTA reported, is the collective brain-child of Leonard Abramson, Edgar Bronfman, and Michael Steinhardt—three of the leading Mega Group members (JTA made no mention of Mega). The Mega Group is expected to kick in $7 million to launch the new organization, with the Israeli Foreign Ministry also pledged to pony up $1 million in startup cash. But, lest there be any confusion about who's in charge at Emet, JTA revealed that "the group consulted with [Malcolm] Hoelein, [Abe] Foxman and other Jewish activists—and only then notified Israel's Foreign Ministry, Foxman said." Hoelein, the executive vice president of the Conference of Presidents of Major American Jewish Organizations, is a fanatical backer of the Sharon war-drive, a view he shared with the just-retired president of the group, Ronald Lauder, a big Sharon financial backer who met with Sharon in September 2000—just before the latter staged his provocation at the Islamic holy sites on the Temple Mount/al-Haram al-Sharif in Jerusalem, triggering the ongoing violence.

The Emet project has been criticized inside Israel, by Foreign Ministry officials and peace activists alike. As JTA reported, "Some Foreign Ministry officials grumbled that American Jews were poaching on their turf. Not surprisingly, they would prefer that any extra money be funneled to the ministry's efforts…. Israel's left appeared concerned that hawkish American Jews will use Emet to push a hard-line approach to the peace process." Steinhardt, Bronfman, and Abramson refused to talk about the project. But the enthusiastic endorsement for Emet from Morton Klein, president of the hawkish Zionist Organization of America, is strong confirmation that the outfit will peddle Sharon's war line. As EIR reported recently, Klein led a delegation of right-wing Zionists and evangelical Christians in a White House meeting, where they threatened a Presidential representative with a cutoff of support, if Bush attempted to interfere in Sharon's war schemes (see Anton Chaitkin, "Temple Mount Fanatics Seek To Blackmail Bush," EIR Aug. 24, 2001).

>>14290828

Mega group

part 5

The Power of Money

The Mega Group story came full circle on May 5, 2001, with the publication of a story in an obscure Israeli online publication, Media Monitors Network, by writer Israel Shamir. Shamir noted, with no lack of irony, the meeting of the Mega Group, which had taken place the previous day at the Manhattan mansion of Edgar Bronfman.

Shamir first described a meeting he had recently had with a Vermont-based psychoanalyst, the nephew of Israel's first Prime Minister, David Ben-Gurion. The nephew prided himself on the fact that his closest friends were Palestinians, and that he rejected the idea of a Jewish "tribal" identity, preferring to view all human beings as brethren.

Shamir observed, "That is the last thing the bosses want. I would not be amazed if they discussed it yesterday, when they met in the Edgar Bronfman mansion in Manhattan. The head of the World Jewish Congress hosted a meeting of the 50 richest and most powerful Jews of the U.S. and Canada. There was no press coverage, no limelight, just a few lines in the newspapers…. They agreed to launch a PR program under the Orwellian codename of 'Truth' with the purpose of influencing American public opinion regarding Israeli policies."

Shamir continued, "The megabucks call themselves 'Mega group.' This name appeared in the media a couple of years ago, as a name for the secret Israeli mole in the upper reaches of the U.S. establishment. It came up in an overheard phone conversation, later denied by the Israeli embassy in Washington, D.C. The newshounds and spook watchers got it wrong. 'Mega' was not an agent, Mega was the boss."

With some bitterness, Shamir wrote, "Megabucks influence us, even more than they influence the U.S. Our politicians are as weak and corrupt as America's and they are easier to swing. Even relative small-timers can cause eruption and bloodshed, like the California bingo-parlor owner [Irving] Moskowitz, who pushed our ex-prime minister Netanyahu to open the tunnel under the Haram al Sharif…. The Megabucks can buy Israel with their spare change. If they wish, we would have peace in Palestine today. But they are not interested in Israel per se…. Megabucks care for themselves, and they need Israel in order to keep the American Jews together, supporting them. That is why they do not mind bloodshed in Palestine, and even a bloody regional war does not scare them."

>>14290834

Mega group

part 6 of 6

Shamir concluded: "In my opinion, Megabucks, rather than forces of Caballa, move the events in the Middle East. It is not magic, just money—but a lot of money. They do not rule America or Israel, but they exercise a lot of influence. Fifty multibillionaires united in one framework present a very real force in the world."

Of course, Shamir does not have the picture precisely right. The Bronfman-centered Mega Group is but one component of an insane and desperate element within the transatlantic financial establishment that is now pressing for a "Clash of Civilizations," as a means of responding to the collapse of their global financial empire, and the threat of a new set of Eurasia-centered cooperative arrangements among nations supplanting their power. But, as far as the Mega puzzle is concerned, Shamir has solved the mystery.

No wonder Mossad boss Yatom scolded his Washington-based underling with the warning, "This is not something we use Mega for."

>>14290683

never noticed those…

>>14290692

global population reduction via PTP22N