Gruelle did not create Raggedy Ann as a tribute to his daughter following her death at 13 from an infected vaccination; note .. it has never been confirmed that a vaccination administered to Marcella was infected nor if the vaccination caused her death directly or instead impacted negatively on an underlying heart condition. Hall notes Gruelle's May 28, 1915, U.S. Patent D47789 application for the design of the prototype that became the Raggedy Ann doll was already in progress around the time that Marcella fell ill, and the artist received final approval by the U.S. Patent office on September 7, 1915, the same month as Marcella's death. Nonetheless, the anti-vaccination movement adopted Raggedy Ann as a symbol, though Marcella died from an infected vaccination, not from the side effects of the vaccination itself.
https://en.m.wikipedia.org/wiki/Raggedy_Ann