Ivermectin, a potential anticancer drug derived from an antiparasitic drug

Highlights

Ivermectin effectively suppresses the proliferation and metastasis of cancer cells and promotes cancer cell death at doses that are nontoxic to normal cells.

Ivermectin shows excellent efficacy against conventional chemotherapy drug-resistant cancer cells and reverses multidrug resistance.

Ivermectin combined with other chemotherapy drugs or targeted drugs has powerful effects on cancer.

The structure of crosstalk centered on PAK1 kinase reveals the mechanism by which ivermectin regulates multiple signaling pathways.

Ivermectin has been used to treat parasitic diseases in humans for many years and can quickly enter clinical trials for the treatment of tumors.

https://www.sciencedirect.com/science/article/abs/pii/S1043661820315152