>>14423799 peptides, anons, peptides !
Anon that posted tge above, where does one get thymozin Alpha?. Pubmed article below
What is Thymosin Alpha-1“product By Becka 2 years ago
Thymosin Alpha-1 is a biologically active peptide derived from prothymosin-alpha. Current hypotheses consider Thymosin Alpha-1 to be the main constituent of Thymosin Fraction-5, and as such it is considered to be the active component that restores the immune function in both athymic animals and animals with dysfunctional thymus glands. Thymosin Alpha-1 was among the first peptide isolates of Thymosin Fraction-5 to be sequenced and thereafter synthetically synthesized.
In humans, the PTMA gene encodes prothymosin-alpha, a 113 amino-acid polypeptide. Thymosin Alpha-1 is a 28 amino-acid fragment of prothymosin-alpha, and research has shown that this fragment derivative enhances the cell-mediated immune component of the human immune system. Its immune actions have enabled it to be used for treating viral infections such as Hepatitis B and Hepatitis C. It has also been incorporated into vaccines as an immune booster. Clinical studies have also shown that Thymosin Alpha-1 can be used to manage neoplasias since they upregulate cytotoxic T-cells which are involved in immune surveillance.
Thymosins
Thymosins are proteins with diverse biological actions. They are found in numerous animal tissues. They were originally isolated from thymic tissues, hence their name Thymosins. The main functions of thymosins are modulation and modification of biological responses. They are also known to stimulate leucopoiesis in the bone marrow. Leucopoiesis refers to the process of production of white blood cells from their stem cell precursors; and as such, endogenous thymosins do improve the immunocompetence status of an individual. Studies done on isolated thymic extracts have shown that two types of thymosins: Thymosin alpha-1 and Thymosin Beta-4 could be synthetically produced and then used therapeutically for immunostimulation and immunomodulation.
Thymosins were discovered in the 1960s as researchers sought to identify, categorize and study the biologically active humoral factors released by the thymus. The studies showed that some isolates from the thymus gland did restore immune functions while other isolates did not. These isolates were collectively termed as Thymosin Fraction-5. Further analysis of Thymosin Fraction-5 showed that it was comprised of about 40 peptides which were collectively termed as thymosins. Electric field studies were used to categorize these thymosins into alpha, beta and gamma fractions. Further molecular studies on the thymosin fractions showed that these fractions are genetically and structurally unrelated. Recent studies on thymosins have shown that thymosin beta-1 is ubiquitin. The studies also showed than thymosins can be produced by cells located outside the thymus. Research also showed that Thymosin alpha-1 administration did promote the differentiation of T-cells in athymic mice (that is, mice lacking the thymus). Thymosin alpha-1 has also been shown to have immune-potentiating actions that do interact with a dysfunctional thymus to reconstitute and normalize the immune status in children suffering from immunodeficiency.
The studies reviewed below have provided conclusive findings that demonstrate that Thymosin alpha-1 can be used clinically to improve the immune status.
Research studies
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Thymosin Alpha-1 and Cellular Immunity.
https://www.peptidesciences.com/blog/thymosin-alpha-1