>>14437527 (lb)
>The FDA approved DES, a "synthetic form of estrogen, was marketed to the expecting mother who preferred to have a healthy baby. It claimed to prevent spontaneous abortion, miscarriage, and premature labor. Studies soon showed that mothers who took DES during the first five months of pregnancy were more likely to suffer from complications with their reproductive systems. The FDA finally banned it in 1971."
and when the FDA reapproved it, it 's uses included post-coital contraceptive in addition to
Several sources from medical literature in the 1970s and 1980s indicate that DES was used as a component of hormone therapy for transgender women.[132][133][134]
In 1973, in an attempt to restrict off-label use of DES as a postcoital contraceptive (which had become prevalent at many university health services following publication of an influential study in 1971 in JAMA) to emergency situations such as rape, an FDA Drug Bulletin was sent to all U.S. physicians and pharmacists that said the FDA had approved, under restricted conditions, postcoital contraceptive use of DES.[135]
https://en.wikipedia.org/wiki/Diethylstilbestrol