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Daniel Horowitz
@RMConservative
Here is all the information on the blood libel against ivermectin and how it is a miracle drug for HUMANS. https://theblaze.com/op-ed/horowitz-fda-disseminates-dangerous-and-libelous-misinformation-against-lifesaving-covid-treatment As for how a drug originally used for river blindness helps against covid, the following is from Dr. Ryan Cole.
Horowitz: FDA disseminates dangerous and libelous misinformation against lifesaving COVID treatment
Does our government believe Africans are not human beings? On Sunday, Surgeon General Vivek Murthy declared, "We've been seeing health misinformation as a problem for years, but the speed, scale and…
theblaze.com
4:11 PM · Aug 23, 2021·Twitter Web App
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Daniel Horowitz
@RMConservative
·
14h
Replying to
@RMConservative
Mechanisms of action of #ivermectin against SARS-CoV-2:
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Inhibits binding at ACE2 an TMPRSS2 keeping the virus from entering our cells
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Blocks alpha/beta importin (the virus cell taxi) keeping it from gettin to the nucleus
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Blocks the viral replicase zipper (RdRp)
Daniel Horowitz
@RMConservative
·
14h
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3-Chimotrypsin protease inhibition (keeps the virus from assembling)
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Ivermectin strengthens our natural antiviral cell activity by increasing our natural interferon
production (this Counters SARSCOV2 activity which inhibits cellular interferon)
Daniel Horowitz
@RMConservative
·
14h
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Decreases IL-6 and other inflammatory cytokines through NF Kappa Beta downregulation,
taking the patient from a cytokine storm to calm.
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Binds NSP14 necessary for viral replication and blocks it (equals less virus).
Daniel Horowitz
@RMConservative
·
14h
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Most important mechanism is inhibiting binding to CD147 receptor on red cells, platelets,
lung and blood cell lining. Ivermectin keeps the virus from binding here and decreases
deadly clotting.
Daniel Horowitz
@RMConservative
·
14h
Now for more detail on each of the mechanisms, per Dr. Cole:
Daniel Horowitz
@RMConservative
·
14h
1) "Ivermectin hinders binding of SARS-COV2 spike protein at the ACE2 receptor . Ivermectin
binds not only to the virus spike, but also to the ACE2 receptor (yes, more strongly than
remdesivir).
Daniel Horowitz
@RMConservative
·
14h
.."This is the primary receptor on our cell surface where the virus binds and then
gets gulped into the cell. If the virus can’t bind, it can’t get in. If it can’t get in, it can’t
replicate. Both the key and the lock are altered and don’t work together in the presence of
IVM."
Daniel Horowitz
@RMConservative
·
14h
"We have heard much about ACE2 but TMPRSS2 is a serine protease that is needed on the
cell surface to prime the Spike protein. Ivermectin inhibits this." https://pubmed.ncbi.nlm.nih.gov/32871846/
https://ncbi.nlm.nih.gov/pmc/articles/PMC7996102/
https://frontiersin.org/articles/10.3389/fmicb.2020.592908/full
https://cell.com/cell/pdf/S0092-8674(20)30229-4.pdf
Molecular Docking Reveals Ivermectin and Remdesivir as Potential Repurposed Drugs Against SARS-CoV-2
SARS-CoV-2 is a newly emerged coronavirus that causes a respiratory disease with variable severity and fatal consequences. It was first reported in Wuhan and subsequently caused a global pandemic….
frontiersin.org
Daniel Horowitz
@RMConservative
·
14h
2) "It binds to the alpha/beta importing and saturates it. This is the “taxi/uber” the virus
uses to ride into the cell to arrive at the area where it would replicate."
Daniel Horowitz
@RMConservative
·
14h
"So ivermectin essentials
takes up that “taxi/uber” seats so the virus has trouble getting a ride in to where it needs to be
to copy itself.
https://pubmed.ncbi.nlm.nih.gov/22417684/ Alpha/Beta importin ivermectin
mechanism information we have known for almost a decade"
Ivermectin is a specific inhibitor of importin α/β-mediated nuclear import able to inhibit replic…
The movement of proteins between the cytoplasm and nucleus mediated by the importin superfamily of proteins is essential to many cellular processes, including differentiation and development, and is…
pubmed.ncbi.nlm.nih.gov