From one bad angle>>>The post exp prophylaxis group treated with this will create new mutants and spread them, even to the vaccinated to amplify more problems…
This is disgusting. Not sure who the experts in the country are.
They are contributing to problems down the line in an effort to make numbers at this point look better.
BET?
I was replying to post from another covo last bread… I don't know this, I think Trump told us during the rally that he took it. anon was arguing trump took mAB so do research before being embarrased, I related it to Trump possibly taking the vaccine and if so would you take it knowing what you know now?
I don't care either way.
I would not promote the vaccine.
There are early studies showing that the multiple mAB coctail being deployed might help prevent escape mutations.
These two started mapping everything, possibly giving them a chance to include in the cocktail a monoclonal antibody that they can make based on the map of possible upcoming mutations (mapped guess)…
—-Tyler Starr and colleagues recently developed a scanning method to map how mutations to the RBD affect its recognition by antibodies. Here, Starr and colleagues leveraged this approach to show how mutations to SARS-CoV-2's RBD affect binding by the antibodies in the REGN-COV2 cocktail and by Eli Lilly's antibody LY-CoV016. The authors focused on mutations to the SARS-CoV-2 RBD that do not strongly disrupt binding to the host receptor (ACE-2), to map how these mutations impact binding to the three anti-SARS-CoV-2 antibodies. The maps identified mutations that escape antibody binding, including, surprisingly, a single mutation that escapes both antibodies in the Regeneron antibody cocktail.
To determine if the escape maps could inform analysis of viral evolution in infected humans, the authors examined deep sequencing data from a persistently infected patient who was treated with REGN-COV2 at day 145 after diagnosis with COVID-19. The analysis identified resistance mutations that arose in this patient. Three of the four escape mutations identified by Starr and team had not been identified in Regeneron's viral cell-culture selections, say the authors, illustrating an advantage of complete maps as used here.
The complete maps also permitted the researchers to assess what escape mutations are already present among circulating SARS-CoV-2. After examining all human-derived SARS-CoV-2 sequences available as of 11 January 2021, they report a substantial number of RBD mutations that escaped one or more of the antibodies are in circulation-
Even with mapping and apporporiate predictions…. the virus will escape and they will have to modify the cocktail… on and on…
Giving it to people as PEP is helping escape regardless.