https://medicine.wustl.edu/news/virus-that-causes-covid-19-can-find-alternate-route-to-infect-cells/
Neuropilin-1 facilitates SARS-CoV-2 cell entry and infectivity
https://science.sciencemag.org/content/sci/early/2020/10/19/science.abd2985.full.pdf
what is this alternate pathway they might be speaking about in this article?
Do you think the monoclonal antibody cocktail can PREVENT escape mutations?
The studies I am reading state they selected 2 antibodies that are broadly neutralizing and PREVENT escape mutations?
If you escape the virus won't be able to live?…
https://pubmed.ncbi.nlm.nih.gov/33973262/
ACE2-based decoy receptors for SARS coronavirus 2
Wenyang Jing 1 , Erik Procko 1 2
Affiliations
PMID: 33973262 PMCID: PMC8242511 DOI: 10.1002/prot.26140
Free PMC article
Abstract
SARS coronavirus 2 is neutralized by proteins that block receptor-binding sites on spikes that project from the viral envelope. In particular, substantial research investment has advanced monoclonal antibody therapies to the clinic where they have shown partial efficacy in reducing viral burden and hospitalization. An alternative is to use the host entry receptor, angiotensin-converting enzyme 2 (ACE2), as a soluble decoy that broadly blocks SARS-associated coronaviruses with limited potential for viral escape. Here, we summarize efforts to engineer higher affinity variants of soluble ACE2 that rival the potency of affinity-matured antibodies. Strategies have also been used to increase the valency of ACE2 decoys for avid spike interactions and to improve pharmacokinetics via IgG fusions. Finally, the intrinsic catalytic activity of ACE2 for the turnover of the vasoconstrictor angiotensin II may directly address COVID-19 symptoms and protect against lung and cardiovascular injury, conferring dual mechanisms of action unachievable by monoclonal antibodies. Soluble ACE2 derivatives therefore have the potential to be next generation therapeutics for addressing the immediate needs of the current pandemic and possible future outbreaks.
This is a decoy receptor.
Also if it iwas native ACE2, a short course could help as opposed to long term treatment leading to upregulation….
But I agree, much more complicated than I can imagine.
This systems interplay reallly got me concerned about spike in general and various mechanisms of imapcting the placenta.
We need a meta analysis on all studies for both.