>>>14511736 List of Ivermectin Articles for normies
Ivermectin - the wonder drug
Ivermectin is widely used in SSA for the treatment of various Neglected Tropical Diseases (NTDs) including onchocerciasis and lymphatic filariasis.
Inhibitory activity of ivermectin on the replication of some single-stranded RNA viruses such as dengue virus, Zika virus or yellow fever virus is largely documented and it´s actually considered as a possible drug for SARS-CoV-2 [43].
Indeed, by inhibiting the viral IMPa/ß1-mediated nuclear import, ivermectin can reduce the SARS-CoV-2 viral load [44].
Two recent clinical trials ivermectin-doxycycline (n=60) VS Hydroxy chloroquine-Azithromycin (n=56) and ivermectin (n=173) VS standard of care (n=107) found a better success on symptoms relief, a reduction of the recovery duration and a lower mortality in the ivermectin treated group [45,46].
However, a pharmacokinetic report estimated that the doses routinely used for the control of parasitic diseases are less likely to lead toSARS-CoV-2 inhibition [47].
Results of larges randomized controlled clinical trials ongoing are awaited to better understand the possible effect of routine ivermectin in SSA.
In 2019, nearly 212 million people were treatment with ivermectin in Africa and mainly in rural areas where the virus spread the least.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7992902/
Published online 2020 Dec 16. doi: 10.11604/pamj.2020.37.352.25254
PMCID: PMC7992902
PMID: 33796166
Unexpected low burden of coronavirus disease 2019 (COVID-19) in sub-Saharan Africa region despite disastrous predictions: reasons and perspectives
Daryl Nzokou Tcheutchoua,1 Aurel Tiakouang Tankeu,2,3 Dominic Leandry Wouna Angong,4 Batakeh Ba Agoons,4 Nathan Yves Yanwou Nguemnang,1 Hugues Clotaire Nana Djeunga,3 and Joseph Kamgno3,4,&
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Abstract
The severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is responsible for the development of a highly contagious disease called coronavirus disease (COVID-19). Ten months after the onset of the pandemic, America and Europe remain the most affected regions. Initially, experts predicted that Africa, the poorest continent with the most vulnerable population and health system, would be greatly affected by the ongoing outbreak. However, 240days after the first confirmed case, Africa is among the least affected region, with lower than expected incident cases and mortality. In this review, we discuss possible explanations and reasons for this unexpected low burden of COVID-19 in Africa. We focus on the characteristics of the virus, specificities of the sub-Saharan African population and local environment.
Keywords: Severe acute respiratory syndrome coronavirus-2, COVID-19, sub-Saharan Africa, burden, explanations, reasons