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>Why all the fuss about Ivermectin?
The Guardian describes ivermectin as horse medicine reminding readers considering taking the drug, “You are not a horse. You are not a cow”, saying it’s a medicine meant for farm animals. The FDA echoed that sentiment in a recent tweet, adding “Seriously, y’all. Stop it,” their word choice making it obvious who the tweet was directed to.
Perhaps the FDA didn’t realize that Barack and Michelle Obama often used the term “y’all” and that some might construe the FDA tweet as racist.
The FDA says ivermectin “can be dangerous and even lethal,” yet they approved it in 1998 and have not pulled it from the market despite it being “dangerous and lethal.” Any medication can be “dangerous and lethal” if misused. People have even overdosed on water.
It is true that ivermectin is also used in animals, as are many drugs approved for human use. This is a list of veterinary drugs with many familiar names of antibiotics, antihypertensives, and anesthetics commonly used by humans. Since these drugs are used in farm animals, should humans stop taking them? That seems a rather unscientific argument against ivermectin, especially coming from the FDA.
And healthcare professionals are not recommending or prescribing animal versions of ivermectin as there is an FDA-approved human formulation.
Does ivermectin work against COVID? That is the bigger question and worthy of investigation, rather than reminding people that they are not cows.
A study published several months ago in the American Journal of Therapeutics concluded,
Meta-analyses based on 18 randomized controlled treatment trials of ivermectin in COVID-19 have found large, statistically significant reductions in mortality, time to clinical recovery, and time to viral clearance. Furthermore, results from numerous controlled prophylaxis trials report significantly reduced risks of contracting COVID-19 with the regular use of ivermectin. Finally, the many examples of ivermectin distribution campaigns leading to rapid population-wide decreases in morbidity and mortality indicate that an oral agent effective in all phases of COVID-19 has been identified.
To my knowledge, these 18 studies have not been retracted, unlike previous studies critical of hydroxychloroquine which were ignominiously retracted by prestigious medical journals like The Lancet and the New England Journal of Medicine.
Yet the medical establishment refuses to even entertain the possibility of some benefit from ivermectin, castigating physicians who want to try it in their patients. 18 studies found benefit. Are they all wrong?
Podcaster Joe Rogan recently contracted COVID and recovered within days of taking a drug cocktail including ivermectin. Was it his drug cocktail, his fitness, or just good luck? Impossible to know but his experience will keep ivermectin in the news.
Highly unvaccinated India had a surge in COVID cases earlier this year which abruptly ended following the widespread use of ivermectin, over the objections and criticism of the WHO. In the one state, Tamil Nadu, that did not use ivermectin, cases tripled instead of dropping by 97 percent as in the rest of the country.
This is anecdotal and could have other explanations but the discovery of penicillin was also anecdotal and observational. Good science should investigate rather than ignore such observations.
The Japanese Medical Association recently endorsed ivermectin for COVID. The US CDC cautioned against it.
There is legal pushback as an Ohio judge ordered a hospital to treat a ventilated COVID patient with ivermectin. After a month on the ventilator, this patient is likely COVID free and ivermectin now will have no benefit, allowing the medical establishment to say “see I told you so” that it wouldn’t help.
By this point, active COVID infection is not the issue; instead, it is weaning off and recovery from long-term life support. The early hydroxychloroquine studies had the same flaw, treating patients too late in the disease course to provide or demonstrate benefit.
These drugs have been proposed for early outpatient treatment, not when patients are seriously ill and near death. Looking for treatment benefits in the wrong patient population will yield expected negative results.
Given how devastating COVID can be and how, despite high levels of vaccination in countries like the US, UK, and Israel, we are seeing surging cases and hospitalizations among the vaccinated, we should be pulling out all the stops in treating this virus.
Medical treatment involves balancing risks and benefits. When FDA-approved medications are used in appropriate doses for appropriate patients, prescribed by competent physicians, the risks tend to be low, and any benefit should be celebrated. Instead, the medical establishment, media, and regulatory authorities are taking the opposite approach. One has to wonder why.