Most monoclonal antibody biologics readily cross the placenta, 2,3 leading to concerns regarding their use during pregnancy and their impact on the fetus and infant, and historical avoidance of their use during pregnancy. However, the last decade has seen a shift in disease management toward tight disease control in pregnant patients and a goal of improving both maternal and fetal outcomes. Achieving clinical remission is recognized as one of the best predictors of favourable pregnancy outcomes,4–7 and a stable disease course, especially in the 6 months before conception, has been associated with improved maternal and fetal outcomes.8–10 This has resulted in an increased use of biologics before conception, during pregnancy and postpartum, with treat-to-target objectives varying for each disease.
The current data are reassuring for low mAb drug transfer to breastmilk, but further studies are needed, including of longer-term effects on infant immunity and childhood development.
https://www.cmaj.ca/content/193/29/E1129
I was wrong! But this is my new train of thought!
The mAB's should be considered invery high-riskgroups for PEP. Forget about giving it to controlled hypertensives and controlled diabetics and just because you are 65 or above doesn't mean shit. Maybe 75, DM, HTN combination might make me think about it.
Early treatment with the mAB's is likely beneficial, although there are other treatment options that are effective and cheaper AND their high-risk groups are skewed.
This could be one of the better treatment options for pregnant females, even for PEP, except it's a risk giving it without further studies. But the mechanisms provide a good basis for that theory.
Fine.
It's free but it's a waste of money and useful product.
It's really frustrating that we can have PROPHYLAXIS and TREATMENT AT ALL STAGES with other PO meds but we are in a way resorting to IV mAB's to such a high degree.
Hey Regeneron, think about it.
Add another antibody or two to different epitopes in the same cocktail…try to use mapping to possibly add an antibody to predicted mutation at the same time. You can really prevent escape. Except the virus is already escaping in people who aren't on your shit.