https://www.youtube.com/watch?v=OS9PoOKfTAw&t=3787s
ima too retarded to summarize the video on this link atm but found the discussion from about 5min-25min helpful. the video is g webb and dr cottrel (and no, i'm not purporting to promote them, just the science) and a bit of a dive.
i might try to summarize once i watch it again and take some notes. my immediate take away was virus-vax cycles will make the innate immune system more susceptible to influenza; specific example cited was 1880 epidemic causing the high death rate of spanish flu. discussion was quite technical.