Anonymous ID: 4c7f6b Sept. 13, 2021, 3:19 p.m. No.14572586   ๐Ÿ—„๏ธ.is ๐Ÿ”—kun

Imagine the panic sent out today.

 

Cryogenic brains/bodies stolen and destroyed. If that isn't a clear message I don't know what it.

 

Their personalities are gonna be wiped out of existence forever.

Anonymous ID: 4c7f6b Sept. 13, 2021, 4:01 p.m. No.14572875   ๐Ÿ—„๏ธ.is ๐Ÿ”—kun

It's not a ridiculous claim.

 

With a 3 fold higher ACE2 expression than even lung tissue., as well as the cleaving protein TMPRSS2, the inflammation damage cascade set into motion by both infection AND (more importantly) ribosomal manufacture of the spike proteins can hypothetically abolutely damage the testis beyond repair. It would also sabotage testosterone production.

 

The testis in patients with COVID-19: virus reservoir or immunization resource?

 

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7658157/

 

Fan and colleagues clearly showed that ACE2 is also expressed in adult human testes (9). Based on scRNA-seq profiling of human testes, Wang and Xu reported that ACE2 is highly expressed in spermatogonia and Leydig and Sertoli cells. Interestingly, ACE2 expression in Leydig and Sertoli cells is about 3-fold higher than that present in AT2 cells that express this enzyme (4.25% versus 1.40%) (1). In addition, a recent study reported that SARS-CoV-2 uses the transmembrane serine protease 2 (TMPRSS2) for viral spike (S) protein priming (3). It was found that TMPRSS2 is highly expressed in spermatogonia and spermatids (1). Gene ontology (GO) enrichment analysis further indicated that GO categories associated with viral reproduction and transmission were positively enriched in ACE2-positive spermatogonia (e.g., NUP133, POLR2A, JUN, RANBP2, RPL12, EIF3L, RPL3, RPL4, RPS19, RPS2, NUP85). In contrast, genes that are involved in spermatogenesis are less expressed in ACE2-positive cells. Thus, the authors hypothesized that SARS-CoV-2 may directly target ACE2-positive spermatogonia and disrupt spermatogenesis. In addition, genes involved in cell junctions and immunity were higher expressed in ACE2-positive Leydig and Sertoli cells compared to ACE2 negative cells. This finding suggests that SARS-CoV-2 may replicate and transfer through cellโ€“cell junctions (1).