https://www.qeios.com/read/KO4C77
That link is full of some very interesting nuggets of information:
-Metformin(Diabetic medication) may play a positive role in reducing the chances of getting Covid-19 and/or dying from it.
Metformin use is associated with reduced mortality rate from coronavirus disease 2019 (COVID-19) infection [43].
On the other hand, metformin is known to inhibit IGF-1 by the reversal of hyperinsulinemia. It ameliorates the pulmonary injury in an experimental model of ARS by PI3K signalling inhibition and IGF-1 decrease [46].
(((In brain, insulin-like growth factor 1 (IGF-1) plays a role in growth and development of all major CNS cell types and their synapse maturation. Increase in the IGF-1 pathway is associated to neuronal developmentalimpairmentand, in particular, to autism spectrum disorder (ASD) )))increase IGF-1=bad=
-Curcuminalsodownregulatesglycogen synthase kinase 3 (GSK-3) and β-catenin pathway [54], that are involved in SARS-CoV-19 infectivity [55], COVID-19 boosted inflammation [56], BBB disruption [57] and FXS pathophysiology [58].
-Summary, curcumin decreases TNF-α, MMP-9 and PI3K/AKT and ERK/NF-kB signalling. Considering all above mentioned, it improves inflammation, tissue damage and deleterious effects of IFG-1, becoming a possible therapeutic agent in both COVID-19 and FXS.