Human soluble ACE2 improves the effect of remdesivir in SARS-CoV-2 infection
https://www.embopress.org/doi/full/10.15252/emmm.202013426
Problem
To date, there are no effective drugs for COVID-19. Only remdesivir has received authorization for COVID-19 and has been shown to improve outcomes but not decrease mortality.
Results
We have demonstrated an additive effect of combination therapy using remdesivir with recombinant soluble ACE2. This combination treatment markedly improved their therapeutic windows against SARS-CoV-2.
>>Lower remdesivir dose needed, less toxic