It has been recently suggested that free-floating Spike proteins released by the destroyed cells previously targeted by vaccines may interact with ACE2 of other cells, thereby promoting ACE2 internalization and degradation [80,81]. This mechanism may enhances the imbalance between Ang II overactivity and Ang1-7 deficiency through the loss of ACE2 receptor activity, which may contribute to trigger inflammation, thrombosis, and other adverse reactions [82,83].
At the beginning of the pandemic, it was assumed that a mild or moderate deficiency of ACE2 could protect from viral infection. To date, this hypothesis appears to be rejected by the evidence that symptoms, clinical presentation and outcome of COVID-19 may be consistently related to molecular changes and dysregulation of the RAAS [13,15,85,86]. The interaction between ACE2 and SARS-CoV-2 Spike protein induces a substantial loss of ACE2 receptor activity from the external site of the cellular membrane. This phenomenon leads to less Ang II inactivation and less generation of Ang1-7 (imbalance between Ang II overactivity and Ang1-7 deficiency), which may ultimately trigger inflammation, thrombosis, and other severe adverse reactions influencing the outcome of COVID-19 [2,3,13,15].
The degree of ACE2 expression and the biological relevance of ACE2 deficiency may vary depending on the presence of specific characteristics and conditions (phenotypes of ACE2 deficiency). Important phenotypes including older age, hypertension, diabetes, cardiovascular disease and COPD [2,3,46] share a variable degree of ACE2 deficiency and are associated with more severe forms of COVID-19. Thus, it is very likely that is not the ‘excess’, but the deficiency of ACE2 receptor activity that complicates the outcome of COVID-19.
In the SARS-CoV-2 era, we may assume that ACE2 receptors are not dangerous Trojan horses, but useful defense weapons against the adverse mechanisms associated with the disease.
https://www.sciencedirect.com/science/article/pii/S0953620521003071
Let's say Trump is right…
The vaccines saved millions of lives….
That can be said about HCQ, Ivermectin, Vitamins, Zinc, Budesonide, Nigella, and other treatments as well…
The major difference is…. you wouldn't have all those adverse side effects, injuries, cancers, deaths, etc from these treatments….
Open-label RCT with 419 patients in Iraq, 160 treated with Nigella Sativa, showing lower mortality and severe cases with treatment. Black seeds 40mg/kg orally once daily for 14 days.
Al-Haidari et al., 1/31/2021, Randomized Controlled Trial, Iraq, Middle East, peer-reviewed, 3 authors.
risk of death, 95.8% lower, RR 0.04, p = 0.001, treatment 0 of 160 (0.0%), control 14 of 259 (5.4%), continuity correction due to zero event (with reciprocal of the contrasting arm).
risk of COVID-19 severe case, 92.6% lower, RR 0.07, p < 0.001, treatment 2 of 160 (1.2%), control 44 of 259 (17.0%).
Effect extraction follows pre-specified rules prioritizing more serious outcomes. For an individual study the most serious outcome may have a smaller number of events and lower statistical signficance, however this provides the strongest evidence for the most serious outcomes when combining the results of many trials.
https://www.researchgate.net/publication/352134969_Clinical_Trial_of_Black_Seeds_Against_COVID_-19_in_Kirkuk_City_Iraq
https://pjmhsonline.com/2021/jan/384.pdf
https://www.researchgate.net/publication/352134969_Clinical_Trial_of_Black_Seeds_Against_COVID_-19_in_Kirkuk_City_Iraq
https://www.medrxiv.org/content/10.1101/2020.10.30.20217364v4
https://www.sciencedirect.com/science/article/pii/S0965229921001102