Anonymous ID: dee576 Oct. 11, 2021, 11:50 p.m. No.14770531   🗄️.is 🔗kun   >>0541

Microbial transformation of quinic acid to shikimic acid by Bacillus megaterium, 2004

 

The production of shikimic acid from quinic acid (1.4 mM) using Gluconobacter oxydans as biocatalyst has been reported [18,19] with both whole cell catalyst and immobilized cell system (57% to 77% bioconversion). In the biotransformation, quinate dehydrogenase (QDH), a classical membrane-bound quinoprotein containing pyrroloquinoline quinine (PQQ) as the coenzyme functions as the primary enzyme in quinate oxidation converting quinic acid to 3-dehydroquinate (3-DHQ) (Figure 1) [9,18]. This 3-DHQ further gets converted to 3-dehydroshikimate (3-DHS) by 3-dehydroquinate dehydratase (DQD). Finally, 3-DHS gets converted to shikimic acid by the action of nicotinamide adenine dinucleotide phosphate (NADP)-dependent shikimate dehydrogenase (SKDH). Entry into the shikimate pathway from quinic acid seems to be advantageous over the classical pathway starting from glucose as there is less number of steps involved. From quinic acid, it is converted to shikimate by three enzymatic steps using microbial biotransformation

Anonymous ID: dee576 Oct. 12, 2021, 1:24 a.m. No.14770793   🗄️.is 🔗kun   >>0812

>>14770784

How about pyrroloquinoline quinine? Is that related to quinine?

Why do we have nicotine receptors in our brains?

Why is nicotinic acid the basis for molecules that deliver energy to our cells?

Come on, use those big words.

Anonymous ID: dee576 Oct. 12, 2021, 1:47 a.m. No.14770827   🗄️.is 🔗kun   >>0837

>>14770808

Take the five-atom ring off nicotine by breaking just one bond and replace it with a COOH group and you're there.

The two molecules are not unrelated. A simple oxidation reaction is all you need to turn nicotine into nicotinic acid.

 

Look at when niacin hit the market.

Or continue to believe that the whole war on tobacco was the government looking out for our best interest, if that's what gets you through the night.

Anonymous ID: dee576 Oct. 12, 2021, 2:02 a.m. No.14770846   🗄️.is 🔗kun   >>0849

Tune in next week when Dr. Science explains that sulfuric acid and sulphur are completely unrelated.

Heah, if life gives you lemons, make citric acid!

Anonymous ID: dee576 Oct. 12, 2021, 2:07 a.m. No.14770851   🗄️.is 🔗kun   >>0857

>>14770845

You don't think your body is capable of a simple oxidation to convert nicotine into nicotinic acid?

How do you think your body gets nicotinic acid if you don't take your little niacin pill?

Anonymous ID: dee576 Oct. 12, 2021, 2:21 a.m. No.14770867   🗄️.is 🔗kun

>>14770859

Nicotine is there in the tobacco in the cigarette.

Smoker inhales, drawing oxygen across the leaf as it heats up and burns.

 

Do you think maybe some of the nicotine gets oxidized?

 

What do we call nicotine that has been oxidized?